Evidence map›Paper›PMID 37728659›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2024

Contribution of extracerebral tracer retention and partial volume effects to sex differences in Flortaucipir-PET signal.

Matthew R Scott, Natalie C Edwards, Michael J Properzi, Heidi Il Jacobs, Julie C Price, Cristina Lois, Michelle E Farrell, Bernard J Hanseeuw, Emma G Thibault, Dorene M Rentz and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Associations of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  2. Tau-PET and CSF MTBR-tau243 comparisons validate increased tau aggregation in females.European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Review
  4. Article
  5. Test-retest performance of [Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 4 countries.

Matthew R ScottDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1404-4437
Natalie C EdwardsDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Michael J ProperziDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Heidi Il JacobsDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Julie C PriceDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Cristina LoisDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Michelle E FarrellDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Bernard J HanseeuwDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Emma G ThibaultDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Dorene M RentzDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Keith A JohnsonDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Reisa A SperlingDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Aaron P SchultzDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0418-0999
Rachel F BuckleyDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Harvard University · USBrigham and Women's Hospital · USBoston University · USCliniques Universitaires Saint-Luc · BE

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Vascular factors, physical activity, and inflammation as modulators of neurodegenerative and cognitive trajectories (Project 2)P01AG036694 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Hyun-Sik Yang · 2010 to 2026
$50.2M
Tracking the origin of tau pathology: dovetailing (pre-)preclinical biomarker trajectoriesR01AG062559 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Heidi Irma Jacobs · 2019 to 2026
$4.8M
The wandering nerve: gateway to boost Alzheimer's disease related cognitive performanceR01AG068062 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JACOBS, HEIDI IRMA · 2021 to 2025
$4.6M
Translation of tau-selective PET radiopharmaceuticals in Alzheimers patientsR01AG052414 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI PRICE, JULIE C, VASDEV, NEIL · 2018 to 2021
$2.7M
In vivo characterization of the PET pharmacokinetic properties of T807 in humansR01AG050436 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PRICE, JULIE C · 2015 to 2017
$1.6M
Sex differences in the progression of Alzheimer's disease: is menopause the key?R00AG061238 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI BUCKLEY, RACHEL FRANCES · 2021 to 2023
$747k
Elevated locus coeruleus metabolism as mechanism driving Alzheimer's disease pathologyR21AG074220 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JACOBS, HEIDI IRMA · 2021 to 2022
$477k
NIA NIH HHS P01 AG036694NIA NIH HHS R00 AG061238NIA NIH HHS R01 AG050436NIA NIH HHS R01 AG052414NIA NIH HHS R01 AG062559NIA NIH HHS R01 AG068062NIA NIH HHS R21 AG074220NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Clinically normal females exhibit higher

Indexed as

Alzheimer DiseaseCognitive DysfunctionBrainCarbolinesCross-Sectional StudiesFemaleHumansMalePositron-Emission TomographySex Characteristicstau Proteins7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indoleCarbolinestau ProteinsExtracerebralflortaucipirpartial volume effectsPETsex

Identifiers

PMID37728659
PMCPMC10905641
OpenAlexW4386878194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.