Evidence map›Paper›PMID 37728612›Full record

ArticleeLife2023

An unexpected role of neutrophils in clearing apoptotic hepatocytes in vivo.

Luyang Cao, Lixiang Ma, Juan Zhao, Xiangyu Wang, Xinzou Fang, Wei Li, Yawen Qi, Yingkui Tang, Jieya Liu, Shengxian Peng and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Neutrophil depletion exacerbatesFood and waterborne parasitology · 2026
    Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 7 institutions in 2 countries.

Luyang Cao *Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Lixiang Ma *Department of Anatomy, Histology & Embryology, Shanghai Medical College, Shanghai, China.
Juan Zhao *Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Xiangyu Wang *Department of Anatomy, Histology & Embryology, Shanghai Medical College, Shanghai, China.ORCID 0000-0001-8605-0727
Xinzou FangDepartment of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Wei LiGuangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou, China.
Yawen QiGuangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou, China.
Yingkui TangDepartment of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Jieya LiuDepartment of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Shengxian PengDepartment of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Li YangDepartment of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Liangxue ZhouDepartment of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Li LiDepartment of Anatomy, Histology & Embryology, Shanghai Medical College, Shanghai, China.ORCID 0000-0002-2374-5203
Xiaobo HuClinical Laboratory, Longhua Hospital, Shanghai University of Traditional Medicine, Shanghai, China.
Yuan JiDepartment of Pathology, Zhongshan Hospital Fudan University, Shanghai, China.
Yingyong HouDepartment of Pathology, Zhongshan Hospital Fudan University, Shanghai, China.
Yi ZhaoDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China.
Xianming ZhangProgram for Lung and Vascular Biology, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, and Department of Pediatrics, Division of Critical Care, Northwestern University Feinberg School of Medicine, Chicago, United States.
You-Yang ZhaoProgram for Lung and Vascular Biology, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, and Department of Pediatrics, Division of Critical Care, Northwestern University Feinberg School of Medicine, Chicago, United States.
Yong ZhaoState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Yuquan WeiDepartment of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Asrar B MalikDepartment of Pharmacology, University of Illinois, College of Medicine, Chicago, United States.
Hexige SaiyinState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Jingsong XuDepartment of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.ORCID 0000-0001-8261-9509
Sichuan University · CNLurie Children's Hospital · USFudan University · CNShanghai Medical College of Fudan University · CNGuangzhou Regenerative Medicine and Health Guangdong Laboratory · CNShanghai University of Traditional Chinese Medicine · CNUniversity of Illinois Urbana-Champaign · US

Funding

Novel mechanisms of obliterative pulmonary vascular remodeling and sever pulmonary arterial hypertensionR01HL133951 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ZHAO, YOU-YANG · 2016 to 2024
$4.9M
Negative regulators of endothelial regeneration in aging lungs and ARDSR01HL164014 · NHLBI · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI ZHAO, YOU-YANG · 2022 to 2025
$2.7M
Novel roles of RNA modifications in the pathogenesis of pulmonary vascular remodeling and PAHR01HL162299 · NHLBI · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI ZHAO, YOU-YANG · 2022 to 2025
$2.6M
Novel mechanisms of endothelial Injury in the pathogenesis of ARDSR01HL148810 · NHLBI · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI ZHAO, YOU-YANG · 2020 to 2023
$2.3M
NHLBI NIH HHS R01 HL133951NHLBI NIH HHS R01 HL148810NHLBI NIH HHS R01 HL162299NHLBI NIH HHS R01 HL164014
6 · The paper itself

Abstract

Billions of apoptotic cells are removed daily in a human adult by professional phagocytes (e.g. macrophages) and neighboring nonprofessional phagocytes (e.g. stromal cells). Despite being a type of professional phagocyte, neutrophils are thought to be excluded from apoptotic sites to avoid tissue inflammation. Here, we report a fundamental and unexpected role of neutrophils as the predominant phagocyte responsible for the clearance of apoptotic hepatic cells in the steady state. In contrast to the engulfment of dead cells by macrophages, neutrophils burrowed directly into apoptotic hepatocytes, a process we term

Indexed as

Autoimmune DiseasesNeutrophilsAdultAnimalsAutoantibodiesHepatocytesHumansMacrophagesMicePhagocytesAutoantibodiesapoptotic clearanceautoimmune diseaseshumanmedicineneutrophils

Identifiers

PMID37728612
PMCPMC10511239
OpenAlexW4362555729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.