ArticleThe EMBO journal2023
High air humidity dampens salicylic acid pathway and NPR1 function to promote plant disease.
Article in The EMBO journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026Review
- Non-Targeted Metabolomics Reveals the Metabolic Differentiation of Rice from Adjacent Small-Scale Producing Areas and Its Response to Climatic and Soil Factors.Foods (Basel, Switzerland) · 2026Article
- The Phylogeny of Brassicaceae YABBYs and theInternational journal of molecular sciences · 2026Article
- The TaMADS2-TaTBL21 Module Enhances Wheat Resistance to Stripe Rust by Activating TaGKL-Mediated Immunity.Plant biotechnology journal · 2026Article
- Optimizing off season chrysanthemum production: influence of covering materials on growth and flowering performance in the low hills of Himachal Pradesh.BMC plant biology · 2026Article
- From gene-for-gene to NLRome-for-effectorome: decoding the dynamic interplay between phytopathogenic effector networks and plant immune systems.FEMS microbiology reviews · 2026Review
- Simultaneous Quantification of Salicylic Acid, Pipecolic Acid, and N-Hydroxypipecolic Acid in Plants Using High-Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Genome-Wide Characterization ofGenes · 2025Article
- Humidity-driven ABA depletion determines plant-pathogen competition for leaf water.Nature communications · 2025Article
- Cellular energy sensor SnRK1 suppresses salicylic acid-dependent and -independent defenses and bacterial resistance inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Regional Variation in Mulberry Leaf Metabolites: A Combined Metabolomic and Environmental Analysis of Biosynthetic Drivers.Metabolites · 2025Article
- Warm temperature suppresses plant systemic acquired resistance by intercepting N-hydroxypipecolic acid biosynthesis.The Plant journal : for cell and molecular biology · 2025Article
- Optimizing greenhouse microclimate for plant pathology: challenges and cooling solutions for pathogen control in arid regions.Frontiers in plant science · 2025Review
- Calcium signaling triggers early high humidity responses inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Practical advice for extracellular vesicle isolation in plant-microbe interactions: Concerns, considerations, and conclusions.Journal of extracellular vesicles · 2024Article
- Delayed Sowing ReducedMicroorganisms · 2024Article
- Cullin-Conciliated Regulation of Plant Immune Responses: Implications for Sustainable Crop Protection.Plants (Basel, Switzerland) · 2024Review
- Microgreens Production: Exploiting Environmental and Cultural Factors for Enhanced Agronomical Benefits.Plants (Basel, Switzerland) · 2024Review
- Light- and Relative Humidity-Regulated Hypersensitive Cell Death and Plant Immunity in Chinese Cabbage Leaves by a Non-adapted Bacteria Xanthomonas campestris pv. vesicatoria.The plant pathology journal · 2024Article
- High air humidity dampens salicylic acid pathway and NPR1 function to promote plant disease.The EMBO journal · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The occurrence of plant disease is determined by interactions among host, pathogen, and environment. Air humidity shapes various aspects of plant physiology and high humidity has long been known to promote numerous phyllosphere diseases. However, the molecular basis of how high humidity interferes with plant immunity to favor disease has remained elusive. Here we show that high humidity is associated with an "immuno-compromised" status in Arabidopsis plants. Furthermore, accumulation and signaling of salicylic acid (SA), an important defense hormone, are significantly inhibited under high humidity. NPR1, an SA receptor and central transcriptional co-activator of SA-responsive genes, is less ubiquitinated and displays a lower promoter binding affinity under high humidity. The cellular ubiquitination machinery, particularly the Cullin 3-based E3 ubiquitin ligase mediating NPR1 protein ubiquitination, is downregulated under high humidity. Importantly, under low humidity the Cullin 3a/b mutant plants phenocopy the low SA gene expression and disease susceptibility that is normally observed under high humidity. Our study uncovers a mechanism by which high humidity dampens a major plant defense pathway and provides new insights into the long-observed air humidity influence on diseases.
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