Evidence map›Paper›PMID 37728118›Full record

ArticleInternational journal of methods in psychiatric research2023

Prevalence, stability, and predictive utility of the Multidimensional Assessment of Preschoolers Scales clinically optimized irritability score: Pragmatic early assessment of mental disorder risk.

Jillian Lee Wiggins, Ana Ureña Rosario, Leigha A MacNeill, Sheila Krogh-Jespersen, Margaret Briggs-Gowan, Justin D Smith, Lauren S Wakschlag

Open access · goldAbstract read
In one paragraph

Article in International journal of methods in psychiatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

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  15. Predictive Utility of Irritability "In Context": Proof-of-Principle for an Early Childhood Mental Health Risk Calculator.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jillian Lee WigginsDepartment of Psychology, San Diego State University, San Diego, California, USA.ORCID 0000-0002-4931-6589
Ana Ureña RosarioDepartment of Psychology, San Diego State University, San Diego, California, USA.
Leigha A MacNeillDepartment of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Sheila Krogh-JespersenInstitute for Innovations in Developmental Sciences, Northwestern University, Evanston, Illinois, USA.
Margaret Briggs-GowanDepartment of Psychiatry, University of Connecticut Health, Farmington, Connecticut, USA.
Justin D SmithDepartment of Population Health Sciences, University of Utah, Salt Lake City, Utah, USA.
Lauren S WakschlagDepartment of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Northwestern University · USSan Diego State University · USUConn Health · USUniversity of Utah · US

Funding

Dimensions of Early Temper Loss and Low Concern: Clinical Utility and MechanismsU01MH082830 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WAKSCHLAG, LAUREN S · 2014 to 2018
$3.9M
Developmental Characterization of Preschool Disruptive BehaviorR01MH082830 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI WAKSCHLAG, LAUREN S · 2009 to 2013
$3.7M
Early Traumatic Stress Exposure: Neurodevelopmental Mechanisms of Clinical RiskU01MH090301 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI BRIGGS-GOWAN, MARGARET J · 2012 to 2014
$2.4M
NIMH NIH HHS 2U01MH082830NIMH NIH HHS R01 MH082830NIMH NIH HHS R01MH082830NIMH NIH HHS U01 MH082830NIMH NIH HHS U01 MH090301
6 · The paper itself

Abstract

objectivesCharacterizing the scope and import of early childhood irritability is essential for real-world actualization of this reliable indicator of transdiagnostic mental health risk. Thus, we utilize pragmatic assessment to establish prevalence, stability, and predictive utility of clinically significant early childhood irritability.

methodsData included two independent, diverse community samples of preschool age children (N = 1857; N = 1490), with a subset enriched for risk (N = 425) assessed longitudinally from early childhood through preadolescence (∼4-9 years old). A validated, brief (2-item) scale pragmatically assessed clinically significant irritability. In the longitudinal subsample, clinical interviews assessed internalizing/externalizing disorders.

resultsOne in five preschool-age children had clinically significant irritability, which was independently replicated. Irritability was highly stable through preadolescence. Children with versus without clinically significant early childhood irritability had greater odds of early onset, persistent internalizing/externalizing disorders. The pragmatic assessment effectively screened out low-risk children and identified 2/3 of children with early-onset, persistent psychopathology.

conclusionsClinically significant early childhood irritability prevalence is akin to the pediatric obesity epidemic and may warrant similar universal screening/intervention. Also, irritability's stability demonstrates the common guidance "they'll grow out of it" to be false. Finally, pragmatic irritability assessment has transdiagnostic predictive power and addresses a need for feasible measures to flag risk.

Indexed as

Mental DisordersPsychotic DisordersChildChild, PreschoolHumansIrritable MoodPrevalencechildhoodirritabilityprevalencepsychopathologystability

Identifiers

PMID37728118
PMCPMC10654826
OpenAlexW4386877784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.