Evidence map›Paper›PMID 37727982›Full record

ArticleInternational journal of cancer2024

Telomere dysfunction in Tert knockout mice delays Braf

Jinglong Zhang, Fan Zhang, Kenneth I Porter, Panshak P Dakup, Shuwen Wang, Gavin P Robertson, Shobhan Gaddameedhi, Jiyue Zhu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jinglong ZhangDepartment of Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.
Fan ZhangDepartment of Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.
Kenneth I PorterDepartment of Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.
Panshak P DakupDepartment of Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.
Shuwen WangDepartment of Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.
Gavin P RobertsonDepartment of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0003-0152-2997
Shobhan GaddameedhiDepartment of Biological Sciences, Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, USA.
Jiyue ZhuDepartment of Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.ORCID 0000-0003-2171-0725
Washington State University Spokane · USNC Department of Health and Human Services · USPennsylvania State University · US

Funding

A mouse model with humanized telomere homeostasisR01AG073423 · NIA · WASHINGTON STATE UNIVERSITY · PI JIYUE ZHU · 2022 to 2026
$2.3M
DNA Repair Mechanisms and Circadian Clock Disruption in the CorneaR01ES030113 · NIEHS · WASHINGTON STATE UNIVERSITY · PI GADDAMEEDHI, SHOBHAN · 2020 to 2025
$2.1M
Regulation of human telomeraseR35GM149529 · NIGMS · WASHINGTON STATE UNIVERSITY · PI JIYUE ZHU · 2023 to 2026
$1.5M
Melanoma Research Alliance 579152NIA NIH HHS R01 AG073423NIEHS NIH HHS R01 ES030113NIGMS NIH HHS R35 GM149529
6 · The paper itself

Abstract

Telomerase activation is a crucial step in melanomagenesis, often occurring because of ultraviolet radiation (UVR)-induced mutations at the telomerase gene (TERT) promoter and rendering TERT transcription in response to the activated Raf-MAP kinase pathway by BRAF

Indexed as

MelanomaProto-Oncogene Proteins B-rafTelomeraseAnimalsMiceMice, Inbred C57BLMice, KnockoutMutationTelomereTumor Suppressor Protein p53Ultraviolet RaysBraf protein, mouseProto-Oncogene Proteins B-rafTelomeraseTert protein, mouseTumor Suppressor Protein p53BRAFmelanomamouse modeltelomerasetelomere dysfunction

Identifiers

PMID37727982
PMCPMC10840707
OpenAlexW4386877699

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.