Trial reportArthritis & rheumatology (Hoboken, N.J.)2024
A Randomized Controlled Neuroimaging Trial of Cognitive Behavioral Therapy for Fibromyalgia Pain.
Trial report in Arthritis & rheumatology (Hoboken, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- The effectiveness of psychological interventions on pain, disability, and psychological symptoms in whiplash-associated disorders: a systematic review and meta-analysis.BMC psychology · 2026Pooled it
- Emerging trends and hotspots in cognitive behavioral therapy for chronic pain: a bibliometric analysis.Frontiers in medicine · 2026Pooled it
- Individualized cognitive-behavioral therapy improves anxiety, depression, sleep quality, hopelessness, and disease severity in fibromyalgia syndrome: a single-blind randomized controlled trial.Rheumatology international · 2026Trial
- New Onset of Fibromyalgia After Exposure to a Combat Environment: A Longitudinal Cohort Study.Arthritis care & research · 2026Article
- Chiropractic Care Is Associated with Frequency-Specific Reorganisation of Triple-Network Brain Dynamics: A Source-Localised EEG Study.Brain sciences · 2026Article
- The WISH 2.0 Intervention for Irritable Bowel Syndrome: Protocol for a Pilot Randomized Controlled Trial.JMIR research protocols · 2026Article
- Therapeutic mechanisms and patients centered outcomes in individualized cognitive behavioral therapy for fibromyalgia syndrome.Rheumatology international · 2026Article
- Impact of cognitive behavioral therapy on attention in patients with fibromyalgia: a randomized controlled trial.Pain reports · 2026Article
- Brain sensory network activity underlies reduced nociceptive initiated and nociplastic pain via acupuncture in fibromyalgia.Communications medicine · 2026Article
- Pain Catastrophizing: Mechanisms and Clinical Implications.Journal of pain research · 2026Review
- Abnormal Brain Structure and Function in People with Shoulder Pain: A Systematic Review of Neuroimaging Studies.Journal of pain research · 2026Review
- Evolving Concepts in the Diagnosis and Management of Fibromyalgia: A Moving Target.Journal of pain research · 2026Review
- Cognitive Behavioral Therapy and Pain Chronification: Neuroimmune Rationale, Evidence Boundaries, and Trial Design Priorities: A Structured Narrative Review.Journal of pain research · 2026Review
- Brain Sensory Network Activity Underlies Reduced Nociceptive-Initiated and Nociplastic Pain via Acupuncture in Fibromyalgia.Research square · 2025Article
- Repeat round of auricular percutaneous electrical nerve field stimulation for pediatric disorders of gut brain interaction.Journal of pediatric gastroenterology and nutrition · 2025Article
- Childhood abuse and health outcomes in patients with fibromyalgia: a cross-sectional exploratory study of the moderating effects of pain catastrophizing and mindfulness.BMC musculoskeletal disorders · 2025Article
- Chronic pain and cognitive dysfunction: clinical manifestations, underlying mechanisms, and emerging therapeutic strategies.Frontiers in neuroscience · 2025Review
- Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024Review
- Neurophysiology of Resilience in Juvenile Fibromyalgia.medRxiv : the preprint server for health sciences · 2024Article
- Beyond pain catastrophizing: rationale and recommendations for targeting trauma in the assessment and treatment of chronic pain.Expert review of neurotherapeutics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveFibromyalgia (FM) is characterized by pervasive pain-related symptomatology and high levels of negative affect. Mind-body treatments such as cognitive behavioral therapy (CBT) appear to foster improvement in FM via reductions in pain-related catastrophizing, a set of negative, pain-amplifying cognitive and emotional processes. However, the neural underpinnings of CBT's catastrophizing-reducing effects remain uncertain. This randomized controlled mechanistic trial was designed to assess CBT's effects on pain catastrophizing and its underlying brain circuitry.
methodsOf 114 enrolled participants, 98 underwent a baseline neuroimaging assessment and were randomized to 8 weeks of individual CBT or a matched FM education control (EDU) condition.
resultsCompared with EDU, CBT produced larger decreases in pain catastrophizing post treatment (P < 0.05) and larger reductions in pain interference and symptom impact. Decreases in pain catastrophizing played a significant role in mediating those functional improvements in the CBT group. At baseline, brain functional connectivity between the ventral posterior cingulate cortex (vPCC), a key node of the default mode network (DMN), and somatomotor and salience network regions was increased during catastrophizing thoughts. Following CBT, vPCC connectivity to somatomotor and salience network areas was reduced.
conclusionOur results suggest clinically important and CBT-specific associations between somatosensory/motor- and salience-processing brain regions and the DMN in chronic pain. These patterns of connectivity may contribute to individual differences (and treatment-related changes) in somatic self-awareness. CBT appears to provide clinical benefits at least partially by reducing pain-related catastrophizing and producing adaptive alterations in DMN functional connectivity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.