Evidence map›Paper›PMID 37727456›Full record

ArticleFrontiers in endocrinology2023

Testis exposure to unopposed/elevated activin A

Penny A F Whiley, Michael C M Luu, Liza O'Donnell, David J Handelsman, Kate L Loveland

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Compensatory mechanisms that maintain androgen production in mice lacking key androgen biosynthetic enzymes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Penny A F WhileyCentre for Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Michael C M LuuCentre for Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Liza O'DonnellCentre for Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia.
David J HandelsmanANZAC Research Institute, University of Sydney, Concord, NSW, Australia.
Kate L LovelandCentre for Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Correct fetal testis development underpins adult male fertility, and TGFβ superfamily ligands control key aspects of this process. Transcripts encoding one such ligand, activin A, are upregulated in testes after sex determination and remain high until after birth. Testis development requires activin signalling; mice lacking activin A (

Indexed as

ActivinsTestisAdultAnimalsDiethylhexyl PhthalateFemaleGerm CellsHumansMaleMicePhthalic AcidsPregnancySteroidsactivin AActivinsDiethylhexyl Phthalatemono-(2-ethylhexyl)phthalatephthalic acidPhthalic AcidsSteroidsgonocyteinhibinMEHPmultinucleated germ cellphthalatespermatogenesistesticular dysgenesis

Identifiers

PMID37727456
PMCPMC10505732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.