ArticleFrontiers in oncology2023
Temporal muscle thickness has no prognostic relevance in patients with high-grade glioma compared to functional scales.
Article in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Frailty evaluation for predicting the survival in patients with glioma: a meta-analysis.Neurosurgical review · 2025Pooled it
- Temporal muscle measurements as predictor for outcome in a cohort of IDH-wildtype glioblastoma patients.Brain & spine · 2026Article
- Added prognostic value of temporal muscle thickness in glioblastoma with age-stratified analysis.Scientific reports · 2025Article
- Impact of frailty in elderly patients undergoing decompressive craniectomy after traumatic brain injury.Neurosurgical review · 2025Article
- The relationship between prognosis and temporal muscle thickness in 102 patients with glioblastoma.Scientific reports · 2024Article
- Temporal Muscle Thickness Compared to Functional Scales as a Prognostic Parameter in Patients with Brain Metastases.Cancers · 2024Article
- Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China.Open medicine (Warsaw, Poland) · 2024Article
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Authors and funding
8 authors.
Funding
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Abstract
Background: GBM research is constantly assessing potential valuable prognostic biomarkers to better understand the disease and prognosticate future outcomes. Measuring temporal muscle thickness (TMT) has appeared to be a promising new surrogate marker for skeletal muscle mass and sarcopenia, which further indicates frailty and predicts overall survival (OS). The aim of this study was to determine its usefulness as a prognostic marker in patients with high-grade glioma compared to functional status scales. Methods: TMT was measured in preoperative axial T1-weighted contrast-enhanced magnetic resonance images in 277 patients who received surgical treatment of newly diagnosed WHO III and IV gliomas in our institution between 2015 and 2020. Clinical Frailty Scale (CFS) and Karnofsky Performance Scale (KPS) were assessed preoperatively and during a follow-up visit. Results: Female gender has shown significant correlation with TMT, while TMT did not correlate with preoperative and follow-up functional scores, age, WHO classification, IDH mutation, MGMT promoter methylation, EGFR and ATRX expression, or 1p/19q co-deletion. No significant prognostic value of TMT could be shown in 6, 12, and 24 months OS, while changes in CFS and KPS proved to have a significant impact. Conclusion: Only female gender, but no other clinical, histological, or molecular marker showed any interrelation with TMT. Functional scores outclass measuring TMT as a reliable prognostic factor for predicting OS in patients with high-grade glioma.
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