ArticleJournal of the Royal Society, Interface2023
Aneurysmal growth in type-B aortic dissection: assessing the impact of patient-specific inlet conditions on key haemodynamic indices.
Article in Journal of the Royal Society, Interface, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Systematic review and meta-analysis of current evidences in endograft therapy vs. medical treatment for Spontaneous Isolated Superior Mesenteric Artery Dissection.Langenbeck's archives of surgery · 2024Pooled it
- False Lumen Haemodynamics in Type B Aortic Dissection: An in Vitro Study Using PIV and Patient-Specific Flexible Phantoms.Annals of biomedical engineering · 2026Article
- Clinical outcomes of external fenestration TEVAR in Stanford type B aortic dissection involving the left subclavian artery: a retrospective study.Frontiers in cardiovascular medicine · 2026Article
- Impact of stent graft geometry on hemodynamics in superior mesenteric artery reconstruction after fenestrated/branched endovascular aneurysm repair.Frontiers in bioengineering and biotechnology · 2026Article
- Effects of vessel morphology on aortic hemodynamics: a statistical shape and CFD investigation.Medical & biological engineering & computing · 2026Article
- Patient-specific digital twins in aortic disease: integrating computational hemodynamics, immune profiling, and precision endovascular strategy.Frontiers in cardiovascular medicine · 2026Review
- Hemodynamic Characterization of Peripheral Arterio-Venous Malformations Using Rapid Contrast-Enhanced MR Imaging: An In Vitro and In Vivo Study.Annals of biomedical engineering · 2025Article
- Impact of Residual Intimal Flap Displacement Post-TEVAR on TBAD Haemodynamics in Compliant, Patient-specific CFD Simulations Informed by MRI.Annals of biomedical engineering · 2025Article
- In Silico, Patient-Specific Assessment of Local Hemodynamic Predictors and Neointimal Hyperplasia Localisation in an Arteriovenous Graft.Annals of biomedical engineering · 2025Article
- Mechanisms of aortic dissection: From pathological changes to experimental andProgress in materials science · 2025Article
- The Role of 4D Flow MRI-derived Wall Shear Stress in Aortic Disease: A Comprehensive Review.Reviews in cardiovascular medicine · 2025Review
- ML-ROM wall shear stress prediction in patient-specific vascular pathologies under a limited clinical training data regime.PloS one · 2025Article
- Computational fluid dynamics modelling of hemodynamics in aortic aneurysm and dissection: a review.Frontiers in bioengineering and biotechnology · 2025Review
- Estimating flow division in aortic branches of diseased aorta: a method for boundary condition specification in CFD analysis.Frontiers in bioengineering and biotechnology · 2025Article
- Cardiovascular computed tomography in cardiovascular disease: An overview of its applications from diagnosis to prediction.Journal of geriatric cardiology : JGC · 2024Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Type-B aortic dissection is a cardiovascular disease in which a tear develops in the intimal layer of the descending aorta, allowing pressurized blood to delaminate the layers of the vessel wall. In medically managed patients, long-term aneurysmal dilatation of the false lumen (FL) is considered virtually inevitable and is associated with poorer disease outcomes. While the pathophysiological mechanisms driving FL dilatation are not yet understood, haemodynamic factors are believed to play a key role. Computational fluid dynamics (CFD) and 4D-flow MRI (4DMR) analyses have revealed correlations between flow helicity, oscillatory wall shear stress and aneurysmal dilatation of the FL. In this study, we compare CFD simulations using a patient-specific, three-dimensional, three-component inlet velocity profile (4D IVP) extracted from 4DMR data against simulations with flow rate-matched uniform and axial velocity profiles that remain widely used in the absence of 4DMR. We also evaluate the influence of measurement errors in 4DMR data by scaling the 4D IVP to the degree of imaging error detected in prior studies. We observe that oscillatory shear and helicity are highly sensitive to inlet velocity distribution and flow volume throughout the FL and conclude that the choice of IVP may greatly affect the future clinical value of simulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.