Evidence map›Paper›PMID 37726758›Full record

ArticleBMC pediatrics2023

A multicentre neonatal interventional randomised controlled trial of nebulized surfactant for preterm infants with respiratory distress: Neo-INSPIRe trial protocol.

Ilse Lategan, David Durand, Michael Harrison, Firdose Nakwa, Lizelle Van Wyk, Sithembiso Velaphi, Alan Horn, Gugu Kali, Roger Soll, Danielle Ehret and 2 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Moving on from clinical animal-derived surfactants to peptide-based synthetic pulmonary surfactant.American journal of physiology. Lung cellular and molecular physiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Ilse LateganDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-8227-0247
David DurandAerogen Pharma, San Mateo, CA, USA.ORCID http://orcid.org/0000-0003-1181-0941
Michael HarrisonDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-6451-9341
Firdose NakwaDepartment of Paediatrics and Child Health, University of the Witwatersrand, Johannesburg, South Africa.ORCID http://orcid.org/0000-0001-8884-2517
Lizelle Van WykDepartment of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-9245-3282
Sithembiso VelaphiDepartment of Paediatrics and Child Health, University of the Witwatersrand, Johannesburg, South Africa.ORCID http://orcid.org/0000-0002-9219-8485
Alan HornDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-7795-4900
Gugu KaliDepartment of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-1426-1207
Roger SollVermont Oxford Network, Burlington, VT, USA.ORCID http://orcid.org/0000-0003-0288-3014
Danielle EhretVermont Oxford Network, Burlington, VT, USA.ORCID http://orcid.org/0000-0003-1215-1124
Heather ZarDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-9046-759X
Lloyd TookeDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa. Lloyd.tooke@uct.ac.za.ORCID http://orcid.org/0000-0001-5905-9996
University of Cape Town · ZAStellenbosch University · ZAUniversity of the Witwatersrand · ZAUniversity of Vermont · USSouth African Medical Research Council · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRespiratory distress syndrome in preterm infants is an important cause of morbidity and mortality. Less invasive methods of surfactant administration, along with the use of continuous positive airway pressure (CPAP), have improved outcomes of preterm infants. Aerosolized surfactant can be given without the need for airway instrumentation and may be employed in areas where these skills are scarce. Recent trials from high-resourced countries utilising aerosolized surfactant have had a low quality of evidence and varying outcomes. METHODS AND ANALYSIS: The Neo-INSPIRe trial is an unblinded, multicentre, randomised trial of a novel aerosolized surfactant drug/device combination. Inclusion criteria include preterm infants of 27-34 ETHICS AND DISSEMINATION: Ethical approval has been granted by the relevant human research ethics committees at University of Cape Town (HREC 681/2022), University of the Witwatersrand HREC (221112) and Stellenbosch University (M23/02/004).

trial registrationPACTR202307490670785.

Indexed as

Pulmonary SurfactantsSurface-Active AgentsDyspneaHumansInfantInfant, NewbornInfant, PrematureLipoproteinsMulticenter Studies as TopicRandomized Controlled Trials as TopicLipoproteinsPulmonary SurfactantsSurface-Active AgentsAerosolizedNebulizedNeonatalPretermRDSSurfactant

Identifiers

PMID37726758
PMCPMC10507916
OpenAlexW4386864641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.