Evidence map›Paper›PMID 37726736›Full record

ArticleBMC pregnancy and childbirth2023

Ultrasonographic characteristics, genetic features, and maternal and fetal outcomes in fetuses with omphalocele in China: a single tertiary center study.

Yanting Que, Meiying Cai, Fang Yang, Qingqiang Ji, Shuqi Zhang, Wenhui Huang, Yashi Gao, Bojing Zhou, Hailong Huang, Hua Cao and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. ERNICA evidence based guideline on omphalocele.Orphanet journal of rare diseases · 2026
    Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yanting Que *College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Meiying Cai *Medical Genetic Diagnosis and Therapy Center, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Key Laboratory for Prenatal Diagnosis and Birth Defects, Fujian Maternity and Child Health Hospital, Fujian Medical University, Fuzhou, China.
Fang Yang *Department of Gynecology, Fujian Maternity and Child Health Hospital, Fuzhou, China.
Qingqiang JiDepartment of Gynecology, Fujian Maternity and Child Health Hospital, Fuzhou, China.
Shuqi ZhangCollege of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Wenhui HuangCollege of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Yashi GaoCollege of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Bojing ZhouCollege of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Hailong HuangMedical Genetic Diagnosis and Therapy Center, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Key Laboratory for Prenatal Diagnosis and Birth Defects, Fujian Maternity and Child Health Hospital, Fujian Medical University, Fuzhou, China. huanghailong@fjmu.edu.cn.
Hua CaoMedical Genetic Diagnosis and Therapy Center, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Key Laboratory for Prenatal Diagnosis and Birth Defects, Fujian Maternity and Child Health Hospital, Fujian Medical University, Fuzhou, China. caohua69@fjmu.edu.cn.
Na LinMedical Genetic Diagnosis and Therapy Center, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Key Laboratory for Prenatal Diagnosis and Birth Defects, Fujian Maternity and Child Health Hospital, Fujian Medical University, Fuzhou, China. linna1088@fjmu.edu.cn.
Fujian Medical University · CNFuzhou Maternity and Child Health Care Hospital · CN

Funding

Fujian Provincial Health Technology Project 2020CXB008Fujian Provincial Health Technology Project 2020GGA020Fujian Provincial Natural Science Foundation 2019J01509Joint Funds for the Innovation of Science and Technology, Fujian Province 2020Y9159Key Project on Science and Technology Program of Fujian Health Commission 2021ZD01002Key Project on the Integration of Industry, Education and Research Collaborative Innovation of Fujian Province 2021YZ034011Natural Science Foundation of Fujian Province 2021J01407
6 · The paper itself

Abstract

backgroundPatients with omphalocele, a midline abdominal wall defect at the umbilical cord base, have a low survival rate. However, the long-term outcomes of fetuses with prenatally diagnosed omphalocele have scarcely been studied. Therefore, we investigated the ultrasonographic features, genetic characteristics, and maternal and fetal outcomes of fetuses with omphalocele and provided a reference for the perinatal management of such cases.

methodsA total of 120 pregnant females with fetal omphalocele were diagnosed using prenatal ultrasonography at the Fujian Provincial Maternity and Child Health Hospital from January 2015 to March 2022. Amniotic fluid or cord blood samples were drawn at different gestational weeks for routine karyotype analysis, chromosomal microarray analysis (CMA) detection, and whole exome sequencing (WES). The maternal and fetal outcomes were followed up.

resultsAmong the 120 fetuses, 27 were diagnosed with isolated omphalocele and 93 with nonisolated omphalocele using prenatal ultrasonography. Cardiac anomalies were the most observed cause in 17 fetuses. Routine karyotyping and CMA were performed on 35 patients, and chromosomal abnormalities were observed in five patients, trisomy 18 in three, trisomy 13 in one, and chromosome 8-11 translocation in one patient; all were non-isolated omphalocele cases. Six nonisolated cases had normal CMA results and conventional karyotype tests, and further WES examination revealed one pathogenic variant and two suspected pathogenic variants. Of the 120 fetuses, 112 were successfully followed up. Eighty of the 112 patients requested pregnancy termination. Seven of the cases died in utero. A 72% 1-year survival rate was observed from the successful 25 live births.

conclusionThe prognosis of fetuses with nonisolated omphalocele varies greatly, and individualized analysis should be performed to determine fetal retention carefully. Routine karyotyping with CMA testing should be provided for fetuses with omphalocele. WES is an option if karyotype and CMA tests are normal. If the fetal karyotype is normal and no associated abnormalities are observed, fetuses with omphalocele could have a high survival rate, and most will have a good prognosis.

Indexed as

Hernia, UmbilicalAmniotic FluidChildChinaFamilyFemaleHumansPregnancyPrenatal CareChromosome microarray analysisKaryotype analysisMaternal and fetal outcomesOmphalocelePrenatal diagnosisWhole exome sequencing

Identifiers

PMID37726736
PMCPMC10510157
OpenAlexW4386850731

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.