Evidence map›Paper›PMID 37726649›Full record

ArticleBMC anesthesiology2023

Pressure- vs. volume-controlled ventilation and their respective impact on dynamic parameters of fluid responsiveness: a cross-over animal study.

Amelie Zitzmann, Tim Bandorf, Jonas Merz, Fabian Müller-Graf, Maria Prütz, Paul Frenkel, Susanne Reuter, Brigitte Vollmar, Nora A Fuentes, Stephan H Böhm and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC anesthesiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amelie ZitzmannDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Medical Centre of Rostock, Schillingallee 35, 18057, Rostock, Germany. amelie.zitzmann@med.uni-rostock.de.
Tim BandorfDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Medical Centre of Rostock, Schillingallee 35, 18057, Rostock, Germany.
Jonas MerzDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Medical Centre of Rostock, Schillingallee 35, 18057, Rostock, Germany.
Fabian Müller-GrafDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Medical Centre of Rostock, Schillingallee 35, 18057, Rostock, Germany.
Maria PrützDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Medical Centre of Rostock, Schillingallee 35, 18057, Rostock, Germany.
Paul FrenkelDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Medical Centre of Rostock, Schillingallee 35, 18057, Rostock, Germany.
Susanne ReuterRudolf-Zenker Institute for Experimental Surgery, University Medical Centre of Rostock, Rostock, Germany.
Brigitte VollmarRudolf-Zenker Institute for Experimental Surgery, University Medical Centre of Rostock, Rostock, Germany.
Nora A FuentesDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Medical Centre of Rostock, Schillingallee 35, 18057, Rostock, Germany.
Stephan H BöhmDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Medical Centre of Rostock, Schillingallee 35, 18057, Rostock, Germany.
Daniel A ReuterDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Medical Centre of Rostock, Schillingallee 35, 18057, Rostock, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and goal of studyPulse pressure variation (PPV) and stroke volume variation (SVV), which are based on the forces caused by controlled mechanical ventilation, are commonly used to predict fluid responsiveness. When PPV and SVV were introduced into clinical practice, volume-controlled ventilation (VCV) with tidal volumes (VT) ≥ 10 ml kg

methodsIn this self-controlled animal study, sixteen anaesthetised, paralysed, and mechanically ventilated (goal: VT 8 ml kg

resultsComplete data sets were available of eight pigs. VT and respiratory rates were similar in both forms. Heart rate, central venous, systolic, diastolic, and mean arterial pressures were not different between VCV and PCV at any IVFS. Peak inspiratory pressure was significantly higher in VCV, while plateau, airway and transpulmonary driving pressures were significantly higher in PCV. However, these higher pressures did not result in different PPVs nor SVVs at any IVFS.

conclusionVCV and PCV at similar tidal volumes and respiratory rates produced PPVs and SVVs without clinically meaningful differences in this experimental setting. Further research is needed to transfer these results to humans.

Indexed as

ArteriesRespirationAnimalsBlood PressureBlood Pressure DeterminationCathetersHumansSwineFluid responsivenessFluid therapyHemodynamic monitoringPositive pressure respirationStroke volume

Identifiers

PMID37726649
PMCPMC10507836

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.