Evidence map›Paper›PMID 37726586›Full record

SynthesisJournal of assisted reproduction and genetics2023

Can endometrial compaction predict live birth rates in assisted reproductive technology cycles? A systematic review and meta-analysis.

E Turkgeldi, S Yildiz, E Kalafat, I Keles, B Ata, G Bozdag

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of assisted reproduction and genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

E TurkgeldiDepartment of Obstetrics and Gynaecology, Koc University, Istanbul, Turkey. engtur@gmail.com.ORCID http://orcid.org/0000-0002-5008-3292
S YildizDepartment of Obstetrics and Gynaecology, Koc University, Istanbul, Turkey.
E KalafatDepartment of Obstetrics and Gynaecology, Koc University, Istanbul, Turkey.
I KelesKoc University Hospital, Assisted Reproduction Unit, Istanbul, Turkey.
B AtaDepartment of Obstetrics and Gynaecology, Koc University, Istanbul, Turkey.
G BozdagDepartment of Obstetrics and Gynaecology, Koc University, Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEndometrial compaction (EC) is defined as the difference in endometrial thickness from the end of the follicular phase to the day of embryo transfer (ET). We aimed to determine the role of EC in predicting assisted reproductive technology (ART) success by conducting a meta-analysis of studies reporting the association between EC and clinical outcomes of ART.

methodsMEDLINE via PubMed, Web of Science, Scopus, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched from the date of inception to May 19, 2023. The primary outcome was live birth rate (LBR) per ET. Secondary outcomes were live birth or ongoing pregnancy per ET, ongoing pregnancy per ET, clinical pregnancy per ET, and miscarriage per clinical pregnancy.

resultsFifteen studies were included. When data from all studies reporting live birth were pooled, overall LBR rates were comparable in cycles showing EC or not [RR = 0.97, 95%CI = 0.92 to 1.02; 10 studies, 11,710 transfer cycles]. In a subgroup of studies that included euploid ET cycles, a similar LBR for patients with and without EC was noted [RR = 0.99, 95%CI = 0.86 to 1.13, 4 studies, 1172 cycles]. The miscarriage rate did not seem to be affected by the presence or absence of EC [RR = 1.06, 95%CI = 0.90 to 1.24; 12 studies].

conclusionThe predictive value of EC in determining LBR is limited, and assessment of EC may no longer be necessary, given these findings.

trial registrationPROSPERO CRD42023410389.

Indexed as

Abortion, SpontaneousBirth RateEmbryo TransferFemaleHumansLive BirthPregnancyPregnancy RateReproductive Techniques, AssistedAssisted reproductionEmbryo transferEndometrial compactionEndometrial thicknessIn vitro fertilizationLive birth

Identifiers

PMID37726586
PMCPMC10643758

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.