Evidence map›Paper›PMID 37726584›Full record

ArticleLangenbeck's archives of surgery2023

Impact of neoadjuvant chemotherapy for locally advanced colon cancer on postoperative complications.

Andrew Lynch, Rodrigo Arean-Sanz, Ana Sofia Ore, Giulio Cataldo, Kristen Crowell, Anne Fabrizio, Thomas E Cataldo, Evangelos Messaris

Abstract read
PubMed Publisher
In one paragraph

Article in Langenbeck's archives of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Andrew LynchColon and Rectal Surgery Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Rodrigo Arean-SanzColon and Rectal Surgery Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Ana Sofia OreColon and Rectal Surgery Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Giulio CataldoColon and Rectal Surgery Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Kristen CrowellColon and Rectal Surgery Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Anne FabrizioColon and Rectal Surgery Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Thomas E CataldoColon and Rectal Surgery Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Evangelos MessarisColon and Rectal Surgery Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. emessari@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · USHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAlthough not considered standard therapy, neoadjuvant chemotherapy (NAC) is an encouraging alternative for selected patients with locally advanced colon cancer (LAC). The aim of this study was to compare 30-day postoperative outcomes between patients undergoing upfront surgery and those undergoing NAC for LAC.

methodsUsing the ACS-NSQIP data from 2016 to 2020, 11,498 patients with LAC were divided into those who underwent upfront colectomy (96.2%) and those who received NAC (3.8%). The primary outcome was a composite outcome encompassing 30-day major postoperative complications. Propensity score matched (PSM) analysis and multivariable logistic regression were performed.

resultsAfter PSM analysis, there was no statistically significant difference in the development of a major complication. NAC was not significantly associated with the primary outcome. Risk factors for postoperative complications were T4 stage, older age, male sex, black race, smoking, dependent status, severe COPD, hypoalbuminemia, and preoperative transfusion. Laparoscopic and robotic surgery was protective.

conclusionNAC did not increase the odds of developing a major complication.

Indexed as

Colonic NeoplasmsLaparoscopyColectomyHumansMaleNeoadjuvant TherapyPostoperative ComplicationsColorectal surgeryLocally advanced colon cancerNeoadjuvant chemotherapyPostoperative complications

Identifiers

PMID37726584
OpenAlexW4386857292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.