Evidence map›Paper›PMID 37726545›Full record

ArticlePediatric research2024

Neonatal resuscitation with continuous chest compressions and high frequency percussive ventilation in preterm lambs.

Evan Giusto, Deepika Sankaran, Amy Lesneski, Houssam Joudi, Morgan Hardie, Victoria Hammitt, Lida Zeinali, Satyan Lakshminrusimha, Payam Vali

Open access · greenAbstract readRandomized Controlled Trial, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Evan GiustoDepartment of Pediatrics, School of Medicine, University of California, Davis, Sacramento, CA, USA. egiusto@ucdavis.edu.ORCID 0000-0003-0364-0057
Deepika SankaranDepartment of Pediatrics, School of Medicine, University of California, Davis, Sacramento, CA, USA.
Amy LesneskiStem Cell Program, School of Medicine, University of California, Davis, Sacramento, CA, USA.
Houssam JoudiDepartment of Pediatrics, School of Medicine, University of California, Davis, Sacramento, CA, USA.
Morgan HardieDepartment of Pediatrics, School of Medicine, University of California, Davis, Sacramento, CA, USA.
Victoria HammittStem Cell Program, School of Medicine, University of California, Davis, Sacramento, CA, USA.
Lida ZeinaliDepartment of Pediatrics, School of Medicine, University of California, Davis, Sacramento, CA, USA.
Satyan LakshminrusimhaDepartment of Pediatrics, School of Medicine, University of California, Davis, Sacramento, CA, USA.
Payam ValiDepartment of Pediatrics, School of Medicine, University of California, Davis, Sacramento, CA, USA.
University of California, Davis · US

Funding

Optimal Oxygenation in Neonatal Lung InjuryR01HD072929 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Satyanarayana Lakshminrusimha · 2012 to 2026
$5.4M
Neonatal Hypovolemic Cardiac Arrest: Role of Early Rapid Volume ResuscitationR03HD109443 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SANKARAN, DEEPIKA · 2023 to 2023
$160k
NICHD NIH HHS R01 HD072929NICHD NIH HHS R03 HD109443
6 · The paper itself

Abstract

backgroundCerebral oxygen delivery (cDO

methodsFourteen lambs in cardiac arrest were randomized to 3:1 C:V resuscitation (90CC + 30 breaths/min) per the Neonatal Resuscitation Program guidelines or CCC + HFPV (120CC + HFPV continuously). Intravenous epinephrine was given every 3 min until return of spontaneous circulation (ROSC).

resultsThere was no difference in the incidence and time to ROSC between both groups. Median (IQR) PaCO

conclusionIn preterm lambs with perinatal cardiac-arrest, continuous chest compressions with HFPV does not improve ROSC but enhances gas exchange and increases cerebral oxygen delivery compared to 3:1 C:V during neonatal resuscitation. IMPACT STATEMENT: Ventilation is the most important intervention in newborn resuscitation. Currently recommended 3:1 compression-to-ventilation ratio is associated with hypercarbia and poor oxygen delivery to the brain. Providing uninterrupted continuous chest compressions during high frequency percussive ventilation is feasible in a lamb model of perinatal cardiac arrest, and demonstrates improved gas exchange and oxygen delivery to the brain. This is the first study in premature lambs evaluating high frequency percussive ventilation with asynchronous chest compressions and lays the groundwork for future clinical studies to optimize gas exchange and hemodynamics during chest compressions in newborns.

Indexed as

Cardiopulmonary ResuscitationHeart ArrestAnimalsHemodynamicsOxygenRespiration, ArtificialSheepSheep, DomesticOxygen

Identifiers

PMID37726545
PMCPMC11840558
OpenAlexW4386857334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.