Evidence map›Paper›PMID 37726267›Full record

ArticleNature communications2023

Network controllability of structural connectomes in the neonatal brain.

Huili Sun, Rongtao Jiang, Wei Dai, Alexander J Dufford, Stephanie Noble, Marisa N Spann, Shi Gu, Dustin Scheinost

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

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  9. Structure-function coupling in the first month of life: Associations with age and attention.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  10. Review
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  17. Controlling the human connectome with spatially diffuse input signals.bioRxiv : the preprint server for biology · 2024
    Article
  18. Edge-centric network control on the human brain structural network.Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Huili SunDepartment of Biomedical Engineering, Yale University, New Haven, CT, 06520, USA. huili.sun@yale.edu.ORCID http://orcid.org/0000-0002-4851-3046
Rongtao JiangDepartment of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, CT, 06510, USA.ORCID http://orcid.org/0000-0003-4657-0079
Wei DaiDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, 06510, USA.
Alexander J DuffordDepartment of Psychiatry and Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, 97239, USA.
Stephanie NobleDepartment of Psychology, Northeastern University, Boston, MA, 02115, USA.ORCID http://orcid.org/0000-0002-4804-5553
Marisa N SpannDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Shi GuSchool of Computer Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China.
Dustin ScheinostDepartment of Biomedical Engineering, Yale University, New Haven, CT, 06520, USA. dustin.scheinost@yale.edu.ORCID http://orcid.org/0000-0002-6301-1167
Yale University · USBoston University · USNew York State Psychiatric InstituteOregon Health & Science University · USUniversity of Electronic Science and Technology of China · CN

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Establishing Early Brain Signatures associated with Maternal Immune Activation ExposureR01MH126133 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Dustin Scheinost, Marisa N Spann · 2022 to 2026
$4.2M
NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH126133
6 · The paper itself

Abstract

White matter connectivity supports diverse cognitive demands by efficiently constraining dynamic brain activity. This efficiency can be inferred from network controllability, which represents the ease with which the brain moves between distinct mental states based on white matter connectivity. However, it remains unclear how brain networks support diverse functions at birth, a time of rapid changes in connectivity. Here, we investigate the development of network controllability during the perinatal period and the effect of preterm birth in 521 neonates. We provide evidence that elements of controllability are exhibited in the infant's brain as early as the third trimester and develop rapidly across the perinatal period. Preterm birth disrupts the development of brain networks and altered the energy required to drive state transitions at different levels. In addition, controllability at birth is associated with cognitive ability at 18 months. Our results suggest network controllability develops rapidly during the perinatal period to support cognitive demands but could be altered by environmental impacts like preterm birth.

Indexed as

ConnectomePremature BirthWhite MatterBrainCognitionFemaleHumansInfantInfant, NewbornPregnancy

Identifiers

PMID37726267
PMCPMC10509217
OpenAlexW4386857996

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.