Evidence map›Paper›PMID 37725920›Full record

ArticleInternational archives of allergy and immunology2024

Safety of Oral Food Challenge for Individuals with Low Egg White and Ovomucoid-Specific IgE Antibodies.

Mika Ogata, Takanobu Yoshida, Jun Kido, Natsuko Nishi, Sachiko Shimomura, Nami Hirai, Masaaki Yanai, Tomoyuki Mizukami, Kimitoshi Nakamura

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In one paragraph

Article in International archives of allergy and immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Mika OgataDepartment of Pediatrics, Graduate School of Medical Sciences Kumamoto University, Kumamoto, Japan.
Takanobu YoshidaDepartment of Pediatrics, Graduate School of Medical Sciences Kumamoto University, Kumamoto, Japan.
Jun KidoDepartment of Pediatrics, Graduate School of Medical Sciences Kumamoto University, Kumamoto, Japan.
Natsuko NishiKumamoto Pediatric Allergy and Immunology Study Group, Kumamoto, Japan.
Sachiko ShimomuraKumamoto Pediatric Allergy and Immunology Study Group, Kumamoto, Japan.
Nami HiraiDepartment of Pediatrics, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan.
Masaaki YanaiDepartment of Pediatrics, Kumamoto Regional Medical Center, Kumamoto, Japan.
Tomoyuki MizukamiDepartment of Pediatrics, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan.
Kimitoshi NakamuraDepartment of Pediatrics, Graduate School of Medical Sciences Kumamoto University, Kumamoto, Japan.
Kumamoto Medical Center · JPKumamoto Industrial Research Institute · JPKumamoto University · JPKumamoto University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDuring an oral food challenge (OFC), there is a risk of adverse reactions, including anaphylaxis. Therefore, the physician should carefully conduct the OFC. This study aimed to evaluate the OFC results in individuals with low levels of egg white (EW)- and ovomucoid (OVM)-specific immunoglobulin E (sIgE) and the safety of a hen's egg (HE) OFC in these individuals.

methodsA total of 2,058 individuals with low EW- or OVM-sIgE underwent HE-OFC at two institutions in Kumamoto prefecture, located in the western area of Japan, between January 1, 2017, and December 31, 2021, within 1 year of recorded sIgE measurements. The ImmunoCAP systems were used to measure sIgEs. The HE-OFC test was performed according to the 2017 Food Allergy Guidelines in an open and unblinded method.

resultsFive hundred and one individuals (24.3%) had low EW-sIgE levels (class 2 or lower), and 926 (45.0%) had low OVM-sIgE levels (class 2 or lower). Individuals with low EW-sIgE had lower total IgE and OVM-sIgE than did those with high EW-sIgE (greater than class 2). Those with low OVM-sIgE had lower total IgE and EW-sIgE than did those with high OVM-sIgE (greater than class 2). Among the individuals with low EW-sIgE, 86.4% (433/501 cases) passed the OFC without symptoms. Among the individuals with low OVF-sIgE, 82.6% (765/926 cases) passed the OFC without symptoms.

conclusionMore than 80% of individuals with suspected IgE-dependent HE allergy and low levels of EW- or OVM-specific IgE were able to consume at least a small amount of HE. As the OFC results are independent of the loading dose in cases with low EW- or OVM-sIgE, a medium-dose HE-OFC may be performed safely in individuals with no history of anaphylaxis.

Indexed as

AnaphylaxisEgg HypersensitivityAllergensAnimalsChickensEgg WhiteFemaleHumansImmunoglobulin EOvomucinAllergensImmunoglobulin EOvomucinHen’s egg allergyOral food challengeSafetySpecific IgE

Identifiers

PMID37725920
PMCPMC10794964
OpenAlexW4386878383

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.