Evidence map›Paper›PMID 37725834›Full record

ArticleDiabetes care2023

Computed Tomography Versus Invasive Coronary Angiography in Patients With Diabetes and Suspected Coronary Artery Disease.

Theodora Benedek, Viktoria Wieske, Bálint Szilveszter, Klaus F Kofoed, Patrick Donnelly, José Rodriguez-Palomares, Andrejs Erglis, Josef Veselka, Gintarė Šakalytė, Nada Čemerlić Ađić and 72 more

Erratum issuedOpen access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

82 authors at 20 institutions in 17 countries.

Theodora BenedekDepartment of Internal Medicine, Clinic of Cardiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania.
Viktoria WieskeDepartment of Radiology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Bálint SzilveszterHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Klaus F KofoedDepartment of Cardiology, Nordsjællands Hospital, University of Copenhagen, Hillerød, Denmark.
Patrick DonnellyDepartment of Cardiology, Southeastern Health and Social Care Trust, Belfast, U.K.
José Rodriguez-PalomaresDepartment of Cardiology, Hospital Universitario Vall d'Hebron, Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain.
Andrejs ErglisDepartment of Cardiology, Paul Stradins Clinical University Hospital, University of Latvia, Riga, Latvia.
Josef VeselkaDepartment of Cardiology, Motol University Hospital, Prague, Czech Republic.
Gintarė ŠakalytėDepartment of Cardiology, Hospital of Lithuanian University of Health Sciences Kaunas Clinics, Cardiology Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Nada Čemerlić AđićFaculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Matthias GutberletDepartment of Radiology, University of Leipzig Heart Centre, Leipzig, Germany.
Ignacio DiezDepartment of Cardiology, Basurto Hospital, Bilbao, Spain.
Gershan DavisDepartment of Cardiology, Aintree University Hospital, Liverpool, U.K.
Elke ZimmermannCounty Clinical Emergency Hospital Targu Mures, Targu Mures, Romania.
Cezary KępkaNational Institute of Cardiology, Warsaw, Poland.
Radosav VidakovicDepartment of Cardiology, Internal Medicine Clinic, Clinical Hospital Center Zemun, Belgrade, Serbia.
Marco FranconeDepartment of Radiological Sciences, Sapienza University of Rome, Italy.
Małgorzata Ilnicka-SuckielDepartment of Cardiology, Provincial Specialist Hospital in Wrocław, Wrocław, Poland.
Fabian PlankDepartment of Internal Medicine III, Department of Cardiology, Innsbruck Medical University, Innsbruck, Austria.
Juhani KnuutiTurku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
Rita FariaDepartment of Cardiology, Centro Hospitalar de Vila Nova de Gaia-Espinho, Vila Nova de Gaia, Portugal.
Stephen SchröderDepartment of Cardiology, Alb Fils Kliniken, Göppingen, Germany.
Colin BerrySchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, U.K.
Luca SabaDepartment of Radiology, Azienda Ospedaliero Universitaria, Cagliari, Italy.
Balazs RuzsicsDepartment of Cardiology, Liverpool University Hospital NHS Foundation Trust, Liverpool, U.K.
Nina RieckmannInstitute of Public Health, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Christine KubiakEuropean Clinical Research Infrastructure Network-European Research Infrastructure Consortium, Paris, France.
Kristian Schultz HansenDepartment of Public Health, Section for Health Services Research, University of Copenhagen, Copenhagen, Denmark.
Jacqueline Müller-NordhornBavarian Cancer Registry, Bavarian Health and Food Safety Authority, Munich, Germany.
Bela MerkelyHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Per E SigvardsenDepartment of Cardiology, Nordsjællands Hospital, University of Copenhagen, Hillerød, Denmark.
Imre BenedekCenter of Advanced Research in Multimodality Cardiac Imaging, CardioMed Medical Center, Targu Mures, Romania.
Clare OrrDepartment of Cardiology, Southeastern Health and Social Care Trust, Belfast, U.K.
Filipa Xavier ValenteDepartment of Cardiology, Hospital Universitario Vall d'Hebron, Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain.
Ligita ZvaigzneDepartment of Cardiology, Paul Stradins Clinical University Hospital, University of Latvia, Riga, Latvia.
Martin HorváthDepartment of Cardiology, Motol University Hospital, Prague, Czech Republic.
Antanas JankauskasDepartment of Cardiology, Hospital of Lithuanian University of Health Sciences Kaunas Clinics, Cardiology Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Filip AđićFaculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Michael WoinkeDepartment of Radiology, University of Leipzig Heart Centre, Leipzig, Germany.
Niall MulvihillDepartment of Cardiology, St. Vincent's University Hospital, Dublin, Ireland.
Iñigo LecumberriDepartment of Cardiology, Basurto Hospital, Bilbao, Spain.
Erica ThwaiteDepartment of Cardiology, Aintree University Hospital, Liverpool, U.K.
Michael LauleDeutsches Herzzentrum der Charité, Department of Cardiology, Angiology and Intensive Care Medicine, Campus Charité Mitte, Berlin, Germany.
Mariusz KrukNational Institute of Cardiology, Warsaw, Poland.
Milica StefanovicDepartment of Cardiology, Internal Medicine Clinic, Clinical Hospital Center Zemun, Belgrade, Serbia.
Massimo ManconeDepartment of Radiological Sciences, Sapienza University of Rome, Italy.
Donata KuśmierzDepartment of Radiology, Provincial Specialist Hospital in Wrocław, Wrocław, Poland.
Gudrun FeuchtnerDepartment of Radiology, Innsbruck Medical University, Innsbruck, Austria.
Mikko PietiläTurku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
Vasco Gama RibeiroDepartment of Cardiology, Centro Hospitalar de Vila Nova de Gaia-Espinho, Vila Nova de Gaia, Portugal.
Tanja DroschDepartment of Cardiology, Alb Fils Kliniken, Göppingen, Germany.
Christian DellesSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, U.K.
Marco MelisDepartment of Radiological Sciences, Sapienza University of Rome, Italy.
Michael FisherDepartment of Cardiology, Liverpool University Hospital NHS Foundation Trust, Liverpool, U.K.
Melinda BoussoussouHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Charlotte KragelundDepartment of Cardiology, Nordsjællands Hospital, University of Copenhagen, Hillerød, Denmark.
Rosca AurelianDepartment of Cardiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania.
Stephanie KellyDepartment of Cardiology, Southeastern Health and Social Care Trust, Belfast, U.K.
Bruno Garcia Del BlancoDepartment of Cardiology, Hospital Universitario Vall d'Hebron, Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain.
Ainhoa RubioDepartment of Cardiology, Basurto Hospital, Bilbao, Spain.
Mihály KárolyiHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Jens D HoveDepartment of Cardiology, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, Denmark.
Ioana RodeanCenter of Advanced Research in Multimodality Cardiac Imaging, CardioMed Medical Center, Targu Mures, Romania.
Susan ReganDepartment of Cardiology, Southeastern Health and Social Care Trust, Belfast, U.K.
Hug Cuéllar CalabriaDepartment of Radiology, Institut de Diagnòstic per la Imatge, Hospital Universitari Vall d'Hebron, Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
László GellérHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Linnea LarsenDepartment of Cardiology, Herlev-Gentofte Hospital, Hellerup, Denmark.
Roxana HodasDepartment of Internal Medicine, Clinic of Cardiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania.
Adriane E NappDepartment of Radiology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Robert HaaseDepartment of Radiology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Sarah FegerDepartment of Radiology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Mahmoud MohamedDepartment of Radiology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Lina M Serna-HiguitaDepartment of Clinical Epidemiology and Applied Biostatistics, Universitätsklinikum Tübingen, Tübingen, Germany.
Konrad NeumannInstitute of Biometry and Clinical Epidemiology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Henryk DregerDeutsches Herzzentrum der Charité, Department of Cardiology, Angiology and Intensive Care Medicine, Campus Charité Mitte, Berlin, Germany.
Matthias RiefDepartment of Radiology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
John DaneshDepartment of Public Health and Primary Care at Cambridge University, Cambridge, U.K.
Melanie EstrellaDepartment of Radiology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Maria BosserdtDepartment of Radiology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Peter MartusDepartment of Clinical Epidemiology and Applied Biostatistics, Universitätsklinikum Tübingen, Tübingen, Germany.
Jonathan D DoddSchool of Medicine, University College Dublin, Dublin, Ireland.ORCID 0000-0002-3476-8793
Marc DeweyDepartment of Radiology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Humboldt-Universität zu Berlin · DESemmelweis University · HUUniversity of Copenhagen · DKBelfast Health and Social Care Trust · GBUniversitat Autònoma de Barcelona · ESUniversity of Liverpool · GBHospital de Basurto · ESUniversitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș · ROAlb Fils Kliniken · DECentro Hospitalar de Vila Nova de Gaia · PTHospital of Lithuanian University of Health Sciences Kaunas Clinics · LTHumanitas University · ITInnsbruck Medical University · ATInstitute of Cardiology · PLLeipzig Heart Institute · DEPauls Stradiņš Clinical University Hospital · LVUniversitätsklinikum Tübingen · DEUniversity College Dublin · IEUniversity Hospital in Motol · CZUniversity of Novi Sad · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare cardiac computed tomography (CT) with invasive coronary angiography (ICA) as the initial strategy in patients with diabetes and stable chest pain. RESEARCH DESIGN AND

methodsThis prespecified analysis of the multicenter DISCHARGE trial in 16 European countries was performed in patients with stable chest pain and intermediate pretest probability of coronary artery disease. The primary end point was a major adverse cardiac event (MACE) (cardiovascular death, nonfatal myocardial infarction, or stroke), and the secondary end point was expanded MACE (including transient ischemic attacks and major procedure-related complications).

resultsFollow-up at a median of 3.5 years was available in 3,541 patients of whom 557 (CT group n = 263 vs. ICA group n = 294) had diabetes and 2,984 (CT group n = 1,536 vs. ICA group n = 1,448) did not. No statistically significant diabetes interaction was found for MACE (P = 0.45), expanded MACE (P = 0.35), or major procedure-related complications (P = 0.49). In both patients with and without diabetes, the rate of MACE did not differ between CT and ICA groups. In patients with diabetes, the expanded MACE end point occurred less frequently in the CT group than in the ICA group (3.8% [10 of 263] vs. 8.2% [24 of 294], hazard ratio [HR] 0.45 [95% CI 0.22-0.95]), as did the major procedure-related complication rate (0.4% [1 of 263] vs. 2.7% [8 of 294], HR 0.30 [95% CI 0.13 - 0.63]).

conclusionsIn patients with diabetes referred for ICA for the investigation of stable chest pain, a CT-first strategy compared with an ICA-first strategy showed no difference in MACE and may potentially be associated with a lower rate of expanded MACE and major procedure-related complications.

Indexed as

Coronary Artery DiseaseDiabetes MellitusChest PainComputed Tomography AngiographyCoronary AngiographyHumansPredictive Value of TestsTomography, X-Ray Computed

Identifiers

PMID37725834
PMCPMC10879471
OpenAlexW4386855846

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.