Evidence map›Paper›PMID 37725638›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

HP6/Umbrea is dispensable for viability and fertility, suggesting essentiality of newly evolved genes is rare.

Sherilyn Grill, Ashley Riley, Monica Selvaraj, Ruth Lehmann

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Escalation of genome defense capacity enables control of an expanding meiotic driver.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sherilyn GrillDepartment of Biology, Whitehead Institute, Massachusetts Institute of Technology, Cambridge, MA 02142.
Ashley RileyDepartment of Biology, Whitehead Institute, Massachusetts Institute of Technology, Cambridge, MA 02142.
Monica SelvarajDepartment of Biology, Whitehead Institute, Massachusetts Institute of Technology, Cambridge, MA 02142.
Ruth LehmannDepartment of Biology, Whitehead Institute, Massachusetts Institute of Technology, Cambridge, MA 02142.ORCID 0000-0002-8454-5651
Whitehead Institute for Biomedical Research · US

Funding

Germ Cell Migration in Drosophila.R37HD041900 · NICHD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LEHMANN, RUTH · 2013 to 2021
$2.6M
Protecting and Sustaining Germ Cell IdentityR01HD110546 · NICHD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI RUTH LEHMANN · 2023 to 2026
$1.7M
Uncovering the Mechanisms that Promote and Maintain Germ Cell IdentityK99HD113821 · NICHD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI GRILL, SHERILYN ANN · 2024 to 2025
$272k
NICHD NIH HHS K99 HD113821NICHD NIH HHS R01 HD110546NICHD NIH HHS R37 HD041900
6 · The paper itself

Abstract

The newly evolved gene Heterochromatin Protein 6 (

Indexed as

Genes, LethalHeterochromatinAnimalsBiological EvolutionChromosomal Proteins, Non-HistoneClustered Regularly Interspaced Short Palindromic RepeatsDrosophilaDrosophila ProteinsFertilityChromosomal Proteins, Non-HistoneDrosophila ProteinsHeterochromatinHP6 protein, Drosophilaevolutiongenetic analysisHP6umbreayoung gene

Identifiers

PMID37725638
PMCPMC10523450
OpenAlexW4386859240

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.