ArticlePloS one2023
Hypotension and cognitive impairment among the elderly: Evidence from the CLHLS.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Clinical outcomes of antihypertensive medication use in people with dementia: a systematic review and meta-analysis.GeroScience · 2026Pooled it
- Association between physical activity score and incident hypertension among Chinese adults aged 65 years and older: a national prospective cohort study.Journal of human hypertension · 2026Article
- Association of Left Ventricular Function With Cerebral Small Vessel Disease and Cognition.Journal of the American Heart Association · 2026Article
- Unmet needs for community-based healthcare services and blood pressure among Chinese older adults: A nationwide longitudinal cohort study.BMC public health · 2026Article
- Real-world assessment of sparsentan's drug safety framework.Renal failure · 2025Article
- Association between residential proximity to major roadways and low muscle mass among Chinese older adults: a nationwide cross-sectional study.BMC public health · 2025Article
- Hypotension with neurovascular changes and cognitive dysfunction: An epidemiological, pathobiological, and treatment review.Chinese medical journal · 2025Review
- Association Between Resting Heart Rate and the Risk of Incident Hypertension Among Older Chinese Adults: A Prospective Cohort Study.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Dynamic relations between longitudinal morphological, behavioral, and emotional indicators and cognitive impairment: evidence from the Chinese Longitudinal Healthy Longevity Survey.BMC public health · 2024Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile high blood pressure has been linked to cognitive impairment, the relationship between low blood pressure, especially hypotension, and cognitive impairment has not been well studied. Therefore, this study aimed to assess the prevalence of hypotension and cognitive impairment in the seniors of China, and the association between hypotension and cognitive function impairment.
methodsThe data was derived from the 2018 wave of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Systolic blood pressures (SBP) and diastolic blood pressures (DBP) were measured by objective examination. The Chinese version of the Mini-Mental State Examination (CMMSE) was used to evaluate the cognitive impairment of the elderly. Generalized linear models were conducted to evaluate the association of hypotension with cognitive impairment.
resultsThe prevalence of hypotension and cognitive impairment in the Chinese elderly were 0.76% and 22.06%, respectively. Participants with hypotension, lower SBP, and lower DBP, had odds ratios of 1.62, 1.38, and 1.48 for cognitive impairment, respectively. Besides, the CMMSE scores decreased by 2.08, 0.86, and 1.08 in the elderly with hypotension, lower SBP, and DBP, compared with those with non-hypotension, higher SBP, and DBP, respectively. Subgroup analyses showed that the association of cognitive impairment with hypotension was stronger in Chinese elderly who had decreased activity of daily living. Moreover, there was statistical evidence of a nonlinear dose-response relationship of SBP and DBP with cognitive impairment (Pnonlinear < 0.05).
conclusionHypotension was a potential risk factor for cognitive impairment of the Chinese elderly, especially for those having decreased activity of daily living. Blood pressure management should be conducted to prevent them from cognitive impairment.
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