Evidence map›Paper›PMID 37725327›Full record

ArticleJournal of epidemiology and global health2023

Low-to-Moderate Arsenic Exposure and Urothelial Tract Cancers with a Long Latent Period of Follow-Up in an Arseniasis Area.

Pei-Ju Liao, Chih-Hung Lee, Shu-Li Wang, Hung-Yi Chiou, Chien-Jen Chen, Chen-June Seak, I-Wen Wu, Kuang-Hung Hsu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of epidemiology and global health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Pei-Ju LiaoInternational Program of Health Informatics and Management, Chang Gung University, Taoyuan, Taiwan.
Chih-Hung LeeDepartment of Dermatology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Shu-Li WangNational Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Hung-Yi ChiouInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan.
Chien-Jen ChenGenomics Research Center, Academia Sinica, Taipei, Taiwan.
Chen-June SeakDepartment of Emergency Medicine, New Taipei Municipal Tucheng Hospital, New Taipei City, Taiwan.
I-Wen WuDivision of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan.
Kuang-Hung HsuDepartment of Emergency Medicine, Lin-Kou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan. khsu@mail.cgu.edu.tw.ORCID 0000-0003-2642-7689
Chang Gung University · TWNational Health Research Institutes · TWGenomics Research Center, Academia Sinica · TWKaohsiung Chang Gung Memorial Hospital · TWKeelung Chang Gung Memorial Hospital · TWMing Chi University of Technology · TW

Funding

CEREBRAL CHEMISTRY IN DEMENTIA AND AGING--TREATMENTSZ01AG000401 · NIA · AGING · PI SHETTY, H U · 1994 to 1998
–
Chang Gung Medical Foundation CMRPD1M0281Chang Gung Medical Foundation CMRPD1M0281, CMRPD1M0282Chang Gung Medical Foundation CMRPD3L0021Chang Gung Medical Foundation CMRPD3L0022Health Aging Research Center of Chang Gung University EMRPD1L0401Health Aging Research Center of Chang Gung University EMRPD1L0451Ministry of Science and Technology, Taiwan 110-2410-H-182-013-MY3Wang Jhan-Yang Charitable Trust Fund WJY 2020-HR-01Wang Jhan-Yang Charitable Trust Fund WJY 2021-HR-01Wang Jhan-Yang Charitable Trust Fund WJY 2022-HR-01
6 · The paper itself

Abstract

backgroundArsenic exposure can cause adverse health effects. The effects of long-term low-to-moderate exposure and methylations remain unclear.

objectiveThis study aims to examine the association between low-to-moderate arsenic exposure and urothelial tract cancers while considering the effects of methylation capacity.

methodsIn this study, 5,811 participants were recruited from an arseniasis area in Taiwan for inorganic arsenic metabolite analysis. This follow-up study was conducted between August 1995 and December 2017. We identified 85 urothelial tract cancers in these participants, including 49 bladder and 36 upper urothelial tract cancer cases. A Cox proportional hazards model was employed.

resultsThe analyses revealed a significant association between concentrations of inorganic arsenic in water > 100 ug/L and bladder cancer occurrence, with a hazard ratio (HR) of 4.88 (95% CI 1.35-17.61). A monotonic trend was observed between concentrations of inorganic arsenic in water (from 0 to > 100 ug/L) and the incidence of urothelial tract cancer, including bladder cancer (p < 0.05) and upper urothelial tract cancers (p < 0.05). Participants with a lower primary methylation index or higher secondary methylation index had a prominent effect.

conclusionsRigorous regulations and active interventions should be considered for populations with susceptible characteristics.

Indexed as

ArsenicArsenicalsUrinary Bladder NeoplasmsFollow-Up StudiesHumansWaterArsenicArsenicalsWaterBladder cancerDose–response relationshipLong latency arsenic exposureMethylation capacityUpper urothelial tract cancers

Identifiers

PMID37725327
PMCPMC10686965
OpenAlexW4386845216

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.