SynthesisInternational journal of colorectal disease2023
Postoperative inflammatory response in colorectal cancer surgery: a meta-analysis.
Synthesis in International journal of colorectal disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Low preoperative adiponectin levels are associated with postoperative systemic inflammatory response following major colorectal cancer surgery.Intensive care medicine experimental · 2026Article
- Minimally invasive colectomy May contribute to a better long-term prognosis for patients when a textbook outcome is not achieved.Surgery today · 2026Article
- The impact of ulinastatin on postoperative clinical outcomes in patients with gastric cancer: a retrospective cohort analysis.Journal of gastrointestinal oncology · 2026Article
- Comparative analysis of short-term outcomes, inflammatory markers, and complications in robotic-assistedJournal of thoracic disease · 2026Article
- Diagnostic accuracy of C-reactive protein in detecting anastomotic leakage after minimally invasive rectal cancer surgery.Surgical endoscopy · 2026Article
- Temporal Dynamic Machine Learning Prediction of Postoperative Gastrointestinal Dysfunction Duration in Esophageal Cancer: Integrating Preoperative and Perioperative Routine Blood Temporal Data and Dynamic Ultrasonic Features.International journal of general medicine · 2026Article
- Inflammatory, Immune-Metabolic, and Vascular Biomarker Trajectories Across Treatment Modalities and Associations with Treatment-Related Complications in Oral Squamous Cell Carcinoma: A Prospective Study in Taiwan.Cancer management and research · 2026Article
- Clinical and aesthetic outcomes of transumbilical single-port versus multi-port laparoscopic ovarian cystectomy.Frontiers in endocrinology · 2026Article
- Nutritional risk score drives postoperative morbidity in colorectal cancer: findings from a LASSO-selected multivariable model in 1013 consecutive patients.Frontiers in nutrition · 2026Article
- Endotoxin in drainage fluid as an early and predictive marker of anastomotic leakage after colorectal surgery.Surgery today · 2026Article
- Predictive value of postoperative C-reactive protein-to-albumin ratio for severe complications following radical gastrectomy in gastric cancer patients.Frontiers in medicine · 2026Article
- Trajectories of Symptom Clusters and Their Predictive Factors in Patients With Colorectal Cancer 3 Months After Surgery: A Longitudinal Study.Cancer medicine · 2025Observational
- Clinical Significance of Blood Cell-Derived Inflammation Markers in Assessing Potential Early and Late Postoperative Complications in Patients with Colorectal Cancer: A Systematic Review.Journal of clinical medicine · 2025Review
- The optimal cut-off value of postoperative day three C-reactive protein to predict for major complications in colorectal cancer patients.Langenbeck's archives of surgery · 2025Article
- Evaluation of potential markers of early infection in patients undergoing elective colorectal malignancy surgery.The Journal of international medical research · 2025Article
- Comparing the effects of laparoscopic radical surgery and traditional open surgery on short-term efficacy and long-term survival in patients with colorectal cancer.Frontiers in surgery · 2025Article
- Minimally invasive versus open surgery among colorectal cancer patients.Bioinformation · 2025Article
- Association of Perioperative Skeletal Muscle Index Change With Outcome in Colorectal Cancer Patients.Journal of cachexia, sarcopenia and muscle · 2024Article
- Comparative analysis of the short and medium-term efficacy of the Da Vinci robotWorld journal of gastrointestinal surgery · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSurgical removal of the cancerous tissue remains the cornerstone of curative treatment for colorectal cancer and results in an inflammatory response. An exaggerated inflammatory response has been implicated in the promotion of tumor proliferation and has shown associations with postoperative complications. Literature on the preferred surgical technique to minimize inflammatory response is inconclusive. Therefore, the aim of this study was to assess the inflammatory response and postoperative incidence of infectious complications following surgery for colorectal cancer.
methodsEmbase, PubMed, and Cochrane databases were searched for RCTs that reported inflammatory parameters as a function of surgical modality only. Data related to CRP or IL-6 levels on postoperative days 1 and 3 and data related to postoperative infections were subject to a pairwise meta-analysis to compare open versus laparoscopic techniques.
resultsThe literature search and screening process yielded 4151 studies. Ten studies met criteria, including 568 patients. Only studies on laparoscopic and open surgery were found. Pooled analyses found lower Il-6 and CRP levels on postoperative day 1 and lower CRP levels on postoperative day 3 for laparoscopic surgery compared to open surgery. However, there was no difference in incidence of postoperative infectious complications.
conclusionThe findings of this study indicate a superior inflammatory profile for laparoscopic surgery compared to an open approach for colorectal cancer surgery. For future research, it would be worthwhile to conduct a randomized controlled trial to compare the postoperative inflammatory response and related clinical outcomes between minimally invasive surgical approaches, including laparoscopic and robot-assisted surgery.
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