Evidence map›Paper›PMID 37725224›Full record

SynthesisAnnals of surgical oncology2024

Risk Factors for Breast Cancer-Related Lymphedema: An Umbrella Review.

Aomei Shen, Wanmin Qiang, Liyuan Zhang, Jingru Bian, Fei Zhu, Zijuan Zhang, Qian Lu

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Preventive effects of progressive resistance training of different intensities on breast cancer-related lymphedema.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  15. Pain and lymphedema characteristics of women with breast cancer-related lymphedema with and without type 2 diabetes mellitus.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Aomei ShenDepartment of Nursing, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Wanmin QiangDepartment of Nursing, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Liyuan ZhangDepartment of Nursing, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Jingru BianDepartment of Nursing, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Fei ZhuSchool of Nursing, Hebei University, Baoding, China.
Zijuan ZhangDivision of Medical and Surgical Nursing, School of Nursing, Peking University, Beijing, China.
Qian LuDivision of Medical and Surgical Nursing, School of Nursing, Peking University, Beijing, China. luqian@bjmu.edu.cn.ORCID http://orcid.org/0000-0003-2611-3284
Peking University · CNTianjin Medical University Cancer Institute and Hospital · CNHebei University · CN

Funding

National Natural Science Foundation of China 72174011
6 · The paper itself

Abstract

backgroundIdentification of risk factors facilitates the prevention of breast cancer-related lymphedema (BCRL). Several published systematic reviews have already addressed the risk factors for BCRL. This study aimed to systematically identify potential risk factors for BCRL and evaluate the quality of evidence.

methodsThe study followed methodologic guidance from the Joanna Briggs Institute, and the Cochrane Handbook. The following electronic databases were systematically searched from inception to 15 November 2022: PubMed, Embase, CINAHL, Web of Science, Scopus, CNKI, SinoMed, Wanfang, JBI Database, Cochrane Database, ProQuest, and PROSPERO. Two authors independently screened studies, extracted data, and assessed methodologic quality using AMSTAR2, risk of bias using ROBIS, and evidence quality using GRADE. The study evaluated overlap, assessed the small-study effect, and calculated the I

resultsThe study included 14 publications comprising 10 meta-analyses and 4 systematic reviews. The authors identified 39 factors and 30 unique meta-analyses. In the study, 13 innate personal trait-related risk factors, such as higher body mass index (BMI) and axillary lymph nodes dissection, showed statistically significant associations with BCRL incidence. Breast reconstruction was found to be a protective factor. The methodologic quality was low or critically low. The majority of the systematic reviews and/or meta-analyses were rated as having a high risk of bias. Evidence quality was low for 22 associations and moderate for 8 associations.

conclusionsThe currently identified risk factors for BCRL all are innate personal trait-related factors. Future well-designed studies and robust meta-analyses are needed to explore potential associations between behavioral-, interpersonal-, and environmental-related factors and BCRL, as well as the role of genetic variations and pathophysiologic factors.

Indexed as

Breast Cancer LymphedemaBreast NeoplasmsLymphedemaFemaleHumansLymph Node ExcisionMeta-Analysis as TopicRisk FactorsSystematic Reviews as TopicBreast neoplasmLymphedemaRisk factorsUmbrella review

Identifiers

PMID37725224
OpenAlexW4386864933

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.