Evidence map›Paper›PMID 37725139›Full record

ArticleApplied microbiology and biotechnology2023

Loop-mediated isothermal amplification assay for screening congenital cytomegalovirus infection in newborns.

Hyeonseek Park, Doo Ri Kim, Areum Shin, Eunjung Jeong, Sohee Son, Jin-Hyun Ahn, So Yoon Ahn, Suk-Joo Choi, Soo-Young Oh, Yun Sil Chang and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Applied microbiology and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Hyeonseek ParkBiomedical Engineering Research Center, Smart Healthcare Research Institute, Samsung Medical Center, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0003-3300-1766
Doo Ri KimDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0001-5233-4043
Areum ShinDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0003-3341-0447
Eunjung JeongBiomedical Engineering Research Center, Smart Healthcare Research Institute, Samsung Medical Center, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-4119-4628
Sohee SonDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-1674-9513
Jin-Hyun AhnDepartment of Microbiology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.ORCID http://orcid.org/0000-0002-9545-9062
So Yoon AhnDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-1821-3173
Suk-Joo ChoiDepartment of Gynecology and Obstetrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-8946-4789
Soo-Young OhDepartment of Gynecology and Obstetrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0003-3002-0048
Yun Sil ChangDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0001-9201-2938
Yae-Jean KimDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. yaejeankim@skku.edu.ORCID http://orcid.org/0000-0002-8367-3424
Minhee KangBiomedical Engineering Research Center, Smart Healthcare Research Institute, Samsung Medical Center, Seoul, Republic of Korea. minhee.kang@samsung.com.ORCID http://orcid.org/0000-0003-0330-7828
Samsung Medical Center · KRSamsung (South Korea) · KRSungkyunkwan University · KR

Funding

Future Medicine 2030 Project of the Samsung Medical Center SMX1230761Korea Health Industry Development Institute (KHIDI) HI20C0377National Research Foundation of Korea (NRF) 2022R1A2C2092242
6 · The paper itself

Abstract

Congenital cytomegalovirus (CMV) infection is a common cause of sensorineural hearing loss and neurodevelopmental impairment in newborns. However, congenital CMV infection cannot be diagnosed using samples collected more than 3 weeks after birth because testing after this time cannot distinguish between congenital infection and postnatal infection. Herein, we developed a robust loop-mediated isothermal amplification (LAMP) assay for the large-scale screening of newborns for congenital CMV infection. In contrast to conventional quantitative polymerase chain reaction (qPCR), which detects CMV within a dynamic range of 1.0 × 10

Indexed as

CytomegalovirusCytomegalovirus InfectionsMolecular Diagnostic TechniquesNeonatal ScreeningNucleic Acid Amplification TechniquesColorimetryDNA, ViralHumansInfant, NewbornSensitivity and SpecificityDNA, ViralCongenital cytomegalovirus infectionLoop-mediated isothermal amplificationNewborn screeningPolymerase chain reaction

Identifiers

PMID37725139
PMCPMC10589182
OpenAlexW4386847416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.