Evidence map›Paper›PMID 37725130›Full record

ReviewWorld journal of urology2023

Consultation on UTUC II Stockholm 2022: diagnostic and prognostic methods-what's around the corner?

Alexandra Grahn, Jonathan A Coleman, Ylva Eriksson, Susanne Gabrielsson, Jonna Skov Madsen, Emma Tham, Kay Thomas, Ben Turney, Per Uhlén, Tino Vollmer and 3 more

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Consultation on UTUC Stockholm 2022.World journal of urology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 6 countries.

Alexandra GrahnDivision of Urology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Jonathan A ColemanDepartment of Surgery/Urology, Memorial Sloan Kettering Cancer Center, Weill-Cornell University Medical College, New York, USA.
Ylva ErikssonC-Medical Urology, Sophiahemmet, Stockholm, Sweden.
Susanne GabrielssonDivision of Immunology and Allergy, Departments of Medicine, and Clinical Immunology and Transfusion Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Jonna Skov MadsenDepartment of Clinical Immunology and Biochemistry, Lillebaelt Hospital, University Hospital of Southern Denmark, Vejle, Denmark.
Emma ThamDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Kay ThomasGuy's Stone Unit, Guy's and St Thomas' Hospital, London, UK.
Ben TurneyDepartment of Urology, Churchill Hospital, Oxford, UK.
Per UhlénDeptartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Tino VollmerDepartment of Hematology and Oncology, Medical Center-University of Freiburg, Freiburg, Germany.
Karsten ZiegerDepartment of Urology, Lillebælt Hospital, Vejle, Denmark.
Palle Jörn Sloth OstherDepartment of Urology, Urological Research Center, Lillebaelt Hospital, University Hospital of Southern Denmark, Vejle, Denmark.
Marianne BrehmerDepartments of Urology and Clinical Sciences, Stockholm South General Hospital Stockholm, Karolinska Institutet, Stockholm, Sweden. marianne.brehmer@ki.se.ORCID http://orcid.org/0000-0001-9232-363X
Karolinska University Hospital · SELillebaelt Hospital · DKKarolinska Institutet · SEChurchill Hospital · GBGuy's Hospital · GBMemorial Sloan Kettering Cancer Center · USSophiahemmet Hospital · SEUniversity of Freiburg · DE

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposeTo map current literature and provide an overview of upcoming future diagnostic and prognostic methods for upper tract urothelial carcinoma (UTUC), including translational medical science.

methodsA scoping review approach was applied to search the literature. Based on the published literature, and the experts own experience and opinions consensus was reached through discussions at the meeting Consultation on UTUC II in Stockholm, September 2022.

resultsThe gene mutational profile of UTUC correlates with stage, grade, prognosis, and response to different therapeutic strategies. Analysis of pathway proteins downstream of known pathogenic mutations might be an alternative approach. Liquid biopsies of cell-free DNA may detect UTUC with a higher sensitivity and specificity than urinary cytology. Extracellular vesicles from tumour cells can be detected in urine and may be used to identify the location of the urothelial carcinoma in the urinary tract. 3D microscopy of UTUC samples may add information in the analysis of tumour stage. Chemokines and chemokine receptors were linked to overall survival and responsiveness to neoadjuvant chemotherapy in muscle-invasive bladder cancer, which is potentially also of interest in UTUC.

conclusionCurrent diagnostic methods for UTUC have shortcomings, especially concerning prognostication, which is important for personalized treatment decisions. There are several upcoming methods that may be of interest for UTUC. Most have been studied for urothelial carcinoma of the bladder, and it is important to keep in mind that UTUC is a different entity and not all methods are adaptable or applicable to UTUC.

Indexed as

Carcinoma, Transitional CellKidney NeoplasmsUreteral NeoplasmsUrinary Bladder NeoplasmsHumansPrognosis3D-microscopyBiomarkersGenomic profilePrognostic markersUpper tract urothelial carcinomaUTUC

Identifiers

PMID37725130
PMCPMC10693501
OpenAlexW4386864758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.