Evidence map›Paper›PMID 37725122›Full record

ArticleEuropean journal of clinical pharmacology2023

Area under the curve of tacrolimus using microsampling devices: towards precision medicine in solid organ transplantation?

Aurélien Couette, Camille Tron, Léonard Golbin, Bénédicte Franck, Pauline Houssel-Debry, Thierry Frouget, Marie-Pascale Morin, Henri Brenier, Michel Rayar, Marie-Clémence Verdier and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of clinical pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Aurélien CouetteUniv Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)-UMR S 1085, F-35000 Rennes, France.
Camille TronUniv Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)-UMR S 1085, F-35000 Rennes, France.
Léonard GolbinFHU SUPORT, Rennes, F-35000, France.
Bénédicte FranckUniv Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)-UMR S 1085, F-35000 Rennes, France.
Pauline Houssel-DebryLiver Disease Unit, Centre Hospitalier Universitaire de Rennes, F-35000 Rennes, France.
Thierry FrougetDepartment of Nephrology, Centre Hospitalier Universitaire de Rennes, F-35000 Rennes, France.
Marie-Pascale MorinDepartment of Nephrology, Centre Hospitalier Universitaire de Rennes, F-35000 Rennes, France.
Henri BrenierDepartment of Nephrology, Centre Hospitalier Universitaire de Rennes, F-35000 Rennes, France.
Michel RayarUniv Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)-UMR S 1085, F-35000 Rennes, France.
Marie-Clémence VerdierUniv Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)-UMR S 1085, F-35000 Rennes, France.
Cécile VigneauUniv Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)-UMR S 1085, F-35000 Rennes, France.
Jonathan ChemounyUniv Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)-UMR S 1085, F-35000 Rennes, France.
Florian LemaitreUniv Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)-UMR S 1085, F-35000 Rennes, France. florian.lemaitre@chu-rennes.fr.ORCID http://orcid.org/0000-0002-0908-3629

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTherapeutic drug monitoring of tacrolimus using trough concentration (C

methodsFifty-one transplant recipients benefited from a complete pharmacokinetic profile using a microsampling approach, and their 24-h AUC were calculated using the trapezoidal method. The correlation with C

resultsWeak correlations were found between 24-h AUC observed and the corresponding C

conclusionTacrolimus C

Indexed as

Organ TransplantationTacrolimusArea Under CurveDrug MonitoringHumansImmunosuppressive AgentsPrecision MedicineTransplant RecipientsImmunosuppressive AgentsTacrolimusCalcineurin inhibitorsDried blood spotsDrug monitoringKidney transplantationLiver transplantationPharmacokinetics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.