Evidence map›Paper›PMID 37724996›Full record

ArticleACS chemical neuroscience2023

Preliminary PET Imaging of Microtubule-Based PET Radioligand [

Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, Naresh Damuka, Mack Miller, Ivan Krizan, Avinash Bansode, Thomas Register, Brett M Frye, Jeongchul Kim, Akiva Mintz and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Amyloid Beta Oligomers as Early Triggers of Neuronal Cytoskeleton Dysfunction in Alzheimer's Disease.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  3. Article
  4. Imaging microtubule dynamics: A new frontier in biomarker development for neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  5. Review
  6. Article
  7. Exploring microtubule dynamics in Alzheimer's disease: Longitudinal assessment using [Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Bhuvanachandra BhoopalDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.ORCID 0000-0002-2129-009X
Krishna Kumar GollapelliDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Naresh DamukaDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Mack MillerDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Ivan KrizanDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Avinash BansodeDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Thomas RegisterDepartment of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Brett M FryeDepartment of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Jeongchul KimDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Akiva MintzDepartment of Radiology, Columbia University School of Medicine, New York, New York 10032, United States.
Miranda OrrDepartment of Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Suzanne CraftDepartment of Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Christopher WhitlowDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Samuel N LockhartDepartment of Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.ORCID 0000-0002-0893-5420
Carol A ShivelyDepartment of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Kiran Kumar Solingapuram SaiDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.ORCID 0000-0002-6442-5169
Wake Forest University · USColumbia University · US

Funding

Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
Vervet Research Colony as a Biomedical ResourceP40OD010965 · OD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Matthew Jorgensen · 2012 to 2026
$14.6M
Development of an Innovative Vervet (Chlorocebus aethiops sabaeus) Model of Early Alzheimer's-like Neuropathology and SymptomatologyR24AG073199 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CRAFT, SUZANNE, SHIVELY, CAROL A. · 2021 to 2024
$5.6M
Evaluating microtubule binding as a potential imaging biomarker for Alzheimer's diseaseR01AG065839 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SOLINGAPURAM SAI, KIRAN · 2020 to 2024
$2.5M
High Resolution Profiling of Senescent Neurons and Their Microenvironments in Postmortem Human Brain Tissue Spanning Eight Decades of LifeR01AG068293 · NIA · WASHINGTON UNIVERSITY · PI ORR, MIRANDA ETHEL · 2020 to 2025
$2.0M
NCATS NIH HHS UL1 TR001420NIA NIH HHS P30 AG072947NIA NIH HHS R01 AG065839NIA NIH HHS R01 AG068293NIA NIH HHS R24 AG073199NIH HHS P40 OD010965
6 · The paper itself

Abstract

The microtubule (MT) instability observed in Alzheimer's disease (AD) is commonly attributed to hyperphosphorylation of the MT-associated protein, tau.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsBiomarkersChlorocebus aethiopsFemaleHumansMicrotubulesPeptide FragmentsPositron-Emission TomographyPrimatesQuinazolinestau ProteinsAmyloid beta-PeptidesBiomarkersPeptide FragmentsQuinazolinestau ProteinsverubulinAlzheimer’s diseasenonhuman primate modelsPositron emission tomography imagingradiotracers

Identifiers

PMID37724996
PMCPMC10966409
OpenAlexW4386861083

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.