Evidence map›Paper›PMID 37724524›Full record

ArticleAutoimmunity2023

SARS-CoV-2 spike-specific regulatory T cells (Treg) expand and develop memory in vaccine recipients suggesting a role for immune regulation in preventing severe symptoms in COVID-19.

Alessandra Franco, Jaeyoon Song, Christina Chambers, Alessandro Sette, Alba Grifoni

Open access · diamondAbstract read
In one paragraph

Article in Autoimmunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

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  7. Regulatory T cell memory: implications for malaria.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alessandra FrancoDepartment of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.ORCID 0000-0002-4840-8182
Jaeyoon SongDepartment of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Christina ChambersDepartment of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Alessandro SetteCenter for Autoimmunity and Inflammation, Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.
Alba GrifoniCenter for Autoimmunity and Inflammation, Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.
University of California San Diego · USLa Jolla Institute for Immunology · US

Funding

The impact of ampicillin and breast milk oligosaccharides on the infant microbiome and immune functionsP50HD106463 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Lars Bode, CHRISTINA CHAMBERS · 2021 to 2026
$19.6M
NICHD NIH HHS P50 HD106463
6 · The paper itself

Abstract

We enrolled healthy subjects that received 2 to 4 injections of mRNA-based vaccination to prevent COVID-19 months to a year from the last vaccine boost, and we found numerous SARS-CoV-2 spike-specific regulatory T cell (Treg) that developed T cell memory as effector memory T cells (T

Indexed as

COVID-19VaccinesHumansSARS-CoV-2T-Lymphocytes, RegulatoryVaccinationVaccinesImmune regulationRegulatory T cells (Treg)SARS-CoV-2T cell memoryVaccine

Identifiers

PMID37724524
PMCPMC12167603
OpenAlexW4386846185

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.