Evidence map›Paper›PMID 37724373›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2023

BATF2 enhances proinflammatory cytokine responses in macrophages and improves early host defense against pulmonary

Rick van der Geest, Hernán F Peñaloza, Zeyu Xiong, Shekina Gonzalez-Ferrer, Xiaojing An, Huihua Li, Hongye Fan, Mohammadreza Tabary, S Mehdi Nouraie, Yanwu Zhao and 5 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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  4. Bioinformatics analysis identifies candidate biomarkers associated with sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Rick van der GeestDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-1973-5934
Hernán F PeñalozaDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-1593-678X
Zeyu XiongDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Shekina Gonzalez-FerrerDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Xiaojing AnDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Huihua LiDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Hongye FanDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Mohammadreza TabaryDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
S Mehdi NouraieDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Yanwu ZhaoDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Yingze ZhangDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0001-6947-2901
Kong ChenDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Jonathan K AlderDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0003-3741-6512
William G BainDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0001-8506-0552
Janet S LeeDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-6812-6043
University of Pittsburgh · US

Funding

Regulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2014 to 2023
$21.3M
Mechanisms of host protection against pathogen-secreted proteases in acute lung injuryR01HL136143 · NHLBI · WASHINGTON UNIVERSITY · PI LEE, JANET SOJUNG · 2017 to 2024
$4.4M
The role of ACOD1 in immunomodulation in intrapulmonary Klebsiella pneumoniae infectionR01HL142084 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, KONG · 2018 to 2021
$2.4M
Patient-Oriented Research in Acute Lung Injury and Host Defense in the ICUK24HL143285 · NHLBI · WASHINGTON UNIVERSITY · PI LEE, JANET SOJUNG · 2019 to 2023
$579k
Platelet factors attenuate alveolar injury during severe pneumoniaIK2BX004886 · VA · VETERANS HEALTH ADMINISTRATION · PI BAIN, WILLIAM G · 2020 to 2024
–
BLRD VA IK2 BX004886NHLBI NIH HHS K24 HL143285NHLBI NIH HHS P01 HL114453NHLBI NIH HHS R01 HL136143NHLBI NIH HHS R01 HL142084
6 · The paper itself

Abstract

Basic leucine zipper transcription factor ATF-like 2 (BATF2) is a transcription factor that is emerging as an important regulator of the innate immune system. BATF2 is among the top upregulated genes in human alveolar macrophages treated with LPS, but the signaling pathways that induce BATF2 expression in response to Gram-negative stimuli are incompletely understood. In addition, the role of BATF2 in the host response to pulmonary infection with a Gram-negative pathogen like

Indexed as

Klebsiella InfectionsPneumoniaAdaptor Proteins, Vesicular TransportAnimalsBasic-Leucine Zipper Transcription FactorsCytokinesHumansKlebsiella pneumoniaeMacrophagesMiceMice, Inbred C57BLAdaptor Proteins, Vesicular TransportBasic-Leucine Zipper Transcription FactorsBATF2 protein, mouseCytokineshost defenseinfectionKlebsiella pneumoniaelung immunitymacrophage function

Identifiers

PMID37724373
PMCPMC11068429
OpenAlexW4386843729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.