ArticleJournal of cellular and molecular medicine2023
Interactive effects of CDKN2B-AS1 gene polymorphism and habitual risk factors on oral cancer.
Article in Journal of cellular and molecular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- The association between XPD rs13181 and rs1799793 polymorphism and oral cancer risk: evidence from a meta-analysis.BMC cancer · 2024Pooled it
- The multistep progression of areca nut-induced oral cancer: a mechanistic roadmap from pathogenesis to precision therapy.Life medicine · 2026Review
- Assessment of genetic susceptibility in patients with oral squamous cell carcinoma: a systematic review and meta-analysis.Communications medicine · 2026Article
- Potential influence of carbonic anhydrase 9 genetic variants and expression levels on the progression of diabetic retinopathy.International journal of medical sciences · 2026Article
- Association ofInternational journal of medical sciences · 2026Article
- Review
- The Impact of LINC-PINT polymorphisms on HNSCC risk in a Chinese han population.Die Naturwissenschaften · 2025Article
- Clinical significance of long non-coding RNA MIR155HG genetic variants and susceptibility to oral cancer.Scientific reports · 2025Article
- Disease-Associated Risk Variants and Expression Levels of the lncRNA, CDKN2B-AS1, Are Associated With the Progression of HCC.Journal of cellular and molecular medicine · 2025Article
- The Impact ofJournal of Cancer · 2025Article
- Article
- Genetic association of NEAT1 gene polymorphism with the progression of colorectal cancer.Journal of Cancer · 2025Article
- The impact of long non-coding RNAJournal of Cancer · 2025Article
- The association between the polymorphism of RAR related orphan receptor beta and the clinical manifestations of oral squamous cell carcinoma.Journal of Cancer · 2025Article
- Associations of the Expression Levels and Risk Variants of CDKN2B-AS1 Long Noncoding RNA With the Susceptibility and Progression of Prostate Cancer.Journal of cellular and molecular medicine · 2024Article
- Article
- Genetic variants of LncRNAs HOTTIP and MEG3 influence nasopharyngeal carcinoma susceptibility and clinicopathologic characteristics in the Southern Chinese population.Infectious agents and cancer · 2024Article
- Article
- Impact of CD44 genetic variants on clinicopathological characteristics of uterine cervical cancer patients.International journal of medical sciences · 2024Article
- Impact ofJournal of Cancer · 2024Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral squamous cell carcinoma (OSCC) is a common malignant disease associated with a high mortality rate and heterogeneous disease aetiology. Cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1), is a long noncoding RNA that has been shown to act as a scaffold, sponge, or signal hub to promote carcinogenesis. Here, we attempted to assess the effect of CDKN2B-AS1 single-nucleotide polymorphisms (SNPs) on the susceptibility to OSCC. Five CDKN2B-AS1 SNPs, including rs564398, rs1333048, rs1537373, rs2151280 and rs8181047, were analysed in 1060 OSCC cases and 1183 cancer-free controls. No significant association of these five SNPs with the risk of developing OSCC was detected between the case and control group. However, while examining the clinical characteristics, patients bearing at least one minor allele of rs1333048 (CA and CC) were more inclined to develop late-stage (stage III/IV, adjusted OR, 1.480; 95% CI, 1.129-1.940; p = 0.005) and large-size (greater than 2 cm in the greatest dimension, adjusted OR, 1.347; 95% CI, 1.028-1.765; p = 0.031) tumours, as compared with those homologous for the major allele (AA). Further stratification analyses demonstrated that this genetic correlation with the advanced stage of disease was observed only in habitual betel quid chewers (adjusted OR, 1.480; 95% CI, 1.076-2.035; p = 0.016) or cigarette smokers (adjusted OR, 1.531; 95% CI, 1.136-2.063; p = 0.005) but not in patients who were not exposed to these major habitual risks. These data reveal an interactive effect of CDKN2B-AS1 rs1333048 with habitual exposure to behavioural risks on the progression of oral cancer.
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