Evidence map›Paper›PMID 37723958›Full record

ArticleCurrent molecular medicine2024

Attenuation of NLRP3 Inflammasome by Cigarette Smoke is Correlated with Decreased Defense Response of Oral Epithelial Cells to

Fan Huang, Ruiqi Xie, Ruowei Li, Liu Liu, Maomao Zhao, Qiong Wang, Weida Liu, Pei Ye, Wenmei Wang, Xiang Wang

Abstract read
In one paragraph

Article in Current molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fan HuangDepartment of Oral Medicine, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.ORCID 0000-0002-3982-7086
Ruiqi XieDepartment of Oral Medicine, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.ORCID 0000-0001-6901-5890
Ruowei LiDepartment of Oral Medicine, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.ORCID 0000-0002-7568-7738
Liu LiuDepartment of Oral Medicine, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Maomao ZhaoDepartment of Oral Medicine, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Qiong WangJiangsu Key Laboratory of Molecular Biology for Skin Disease and STIs, Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Nanjing, China.
Weida LiuJiangsu Key Laboratory of Molecular Biology for Skin Disease and STIs, Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Nanjing, China.
Pei YeDepartment of Oral Medicine, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Wenmei WangDepartment of Oral Medicine, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Xiang WangDepartment of Oral Medicine, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Funding

Key Project of Science and Technology Department of Jiangsu Province BL2014018Nanjing Medical Science and Technique Development Foundation ZKX17033National Natural Scientific Foundation of China 81870767, 81570978Project of Jiangsu Provincial Medical Youth Talent QNRC2016118
6 · The paper itself

Abstract

backgroundIt is well recognized that both smoke and

methodsThe present study was designed to explore the effects of cigarette smoke and

resultsMicroscopically, Leuk-1 cells exerted a defense response to

conclusionOur results suggested that in oral epithelial cells, the NLRP3 inflammasome might be one of the target pathways by which CSE attenuates innate immunity and leads to oral disorders.

Indexed as

Candida albicansEpithelial CellsInflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinCell LineHumansImmunity, InnateInterleukin-18Mouth MucosaSignal TransductionSmokeInflammasomesInterleukin-18Interleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanSmokeCandida albicanscigarette smokehost defense.NLRP3 inflammasomeoral epithelial cellssignal pathway

Identifiers

PMID37723958
PMCPMC11327737

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.