Evidence map›Paper›PMID 37723538›Full record

ArticleBMC pediatrics2023

Factors associated with afebrile presentation and delayed defervescence of bacterial meningitis in children under 3 years of age: a multi-centre retrospective analysis.

Lin He, Haijing Li, Zhigang Zhang, Hejia Ge, Hongwei Wang, Mengquan Zhu, Zhiwei Xu, Jiening Zhang, Sheng Fang, Chuanze Hu and 13 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 14 institutions in 1 country.

Lin HeDepartment of Infectious Diseases, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health, Hangzhou, China.
Haijing LiDepartment of Pediatric, Shaoxing Maternity and Child Health Care Hospital, Shaoxing, China.
Zhigang ZhangDepartment of Pediatric, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China.
Hejia GeDepartment of Pediatric, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
Hongwei WangDepartment of Pediatric, Shaoxing Keqiao Women and Children's Hospital, Shaoxing, China.
Mengquan ZhuDepartment of Pediatric, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Zhiwei XuDepartment of Pediatric, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Jiening ZhangDepartment of Pediatric, Jiaxing Maternity and Child Health Care Hospital, Jiaxing, China.
Sheng FangDepartment of Pediatric, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China.
Chuanze HuDepartment of Pediatric, Jinhua Maternal and Child Health Care Hospital, Jinhua, China.
Lijun QianDepartment of Pediatric, Lishui Central Hospital and Fifth Affiliated Hospital of Wenzhou Medical College, Lishui, China.
Huifang XuDepartment of Pediatric, Lanxi People's Hospital, Lanxi, China.
Yinna YaoDepartment of Pediatric, Zhuji People's Hospital of Zhejiang Province, Zhuji, China.
Shengfu YuanDepartment of Pediatric, Yuyao People's Hospital, Yuyao, China.
Jiajun ZhuDivision of Neonatology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Chaosheng LuDepartment of Pediatric, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jishan ZhengDepartment of Pediatric, Ningbo Women and Children Hospital, Ningbo, China.
Junsheng LiDepartment of Pediatric, Lishui Maternity and Child Health Care Hospital, Lishui, China.
Qi JiangDepartment of Pediatric, Huzhou Maternity and Child Health Care Hospital, Huzhou, China.
Huiqing XuDepartment of Pediatric, Ningbo Women and Children Hospital, Ningbo, China.
Lihua ChenDivision of Neonatology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health, Hangzhou, China.
Shiqiang ShangDepartment of Clinical Laboratory, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health, Hangzhou, China. shangsq@zju.edu.cn.
Yinghu ChenDepartment of Infectious Diseases, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health, Hangzhou, China. cyh18@zju.edu.cn.
Children's Hospital of Zhejiang University · CNSecond Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University · CNShaoxing City Women and Children Hospital · CNWenzhou Medical University · CNHuzhou Women and Children's Hospital · CNJiaxing University · CNLishui Central Hospital · CNLishui Maternity and Child Health Care Hospital · CNTaizhou University · CNWomen's Hospital, School of Medicine, Zhejiang University · CNWuxi People's Hospital · CNYuxian People's Hospital · CNZhejiang University · CNZhuhai People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis multi-center study aimed to identify factors affecting fever and delayed defervescence in bacterial meningitis (BM) patients under 3 years of age because of the variability of fever in this patient population.

methodsOnly BM patients under 3 years treated at 49 centers in China from November 2018 to end-April 2021 were included in the study. Univariate and multivariate logistic regression analyses were performed to determine factors associated with afebrile presentation and fever of delayed defervescence.

resultsA total of 863 BM patients under 3 years were included in the study. Coagulase negative staphylococcus was associated with afebrile presentation (OR = 1.176), while septicaemia and ear-nose-throat infections were associated with fever (P < 0.05). The patients with fever were assigned into early and delayed defervescence groups based on defervescence time (less than and more than or equal to one week). Furthermore, Streptococcus agalactiae meningitis (OR = 1.124), concomitant gastrointestinal infection (OR = 1.276), encephalomalacia (or = 1.339), and subdural effusion (OR = 1.454) were independently associated with delayed defervescence (all P < 0.05).

conclusionsThe findings can aid in the efficient utilization of fever in auxiliary diagnosis and evaluating the condition of the disease.

Indexed as

Meningitis, BacterialSepsisStreptococcal InfectionsChildChild, PreschoolChinaFeverHumansRetrospective StudiesBacterial meningitisChildrenDefervescence timeFever

Identifiers

PMID37723538
PMCPMC10507889
OpenAlexW4386831055

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.