ArticleBMC psychiatry2023
Dietary niacin intake in relation to depression among adults: a population-based study.
Article in BMC psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Inverse Association Between Dietary Niacin Intake and Prevalence of Depressive Symptoms in Adults With Metabolic-Associated Fatty Liver Disease: A Cross-Sectional Study.Food science & nutrition · 2026Article
- Association of dietary niacin intake with cardiovascular-kidney-metabolic syndrome risk and mortality.American journal of preventive cardiology · 2026Article
- The Association Between Dietary Fiber Intake and Depression Among US Adults: A Cross-Sectional Study Based on NHANES Data From 2005 to 2020.Food science & nutrition · 2025Article
- Characterizing metabolomic and proteomic changes in depression: a systematic analysis.Molecular psychiatry · 2025Article
- Association between niacin intake and osteoarthritis in the US population based on NHANES 1999-2018.Scientific reports · 2025Article
- Association between niacin intake and chronic kidney disease in male participants-a cross-sectional study from the NHANES (2005-2018).Frontiers in nutrition · 2025Article
- Article
- Niacin intake and mortality (total and cardiovascular disease) in patients with cardiovascular disease: Insights from NHANES 2003-2018.Nutrition journal · 2024Article
- Article
- Association between pregnancy loss and depressive symptoms in women: a population-based study.BMC psychiatry · 2024Article
- Article
- Association between dietary intake of niacin and stroke in the US residents: evidence from national health and nutrition examination survey (NHANES) 1999-2018.Frontiers in nutrition · 2024Article
- Association between dietary niacin intake and Helicobacter pylori seropositivity in US adults: A cross-sectional study.PloS one · 2024Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have shown that an antioxidant diet is a protective factor against depression. However, the association between niacin, an important antioxidant consumed from the diet, and depression has received little attention. Therefore, we explored the association between niacin intake and depression through a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2016.
methodsDepression was measured using the Patient Health Questionnaire (PHQ-9, score ≥ 10). Niacin intake was assessed through 24-h dietary recall interviews. The relationship of niacin intake with depression among adults in US was assessed by using a weighted multiple logistic regression model with subgroup analysis. Non-linear associations were explored using restricted cubic spline models. And we used a two-piece-wise logistic regression model with smoothing to explore the threshold for association between them.
resultsA total of 16,098 adults were included in this study. Compared with individuals with lowest niacin intake Q1 (≤ 15.96 mg/day), the adjusted OR values for dietary niacin intake and depression in Q2 (15.97-22.86 mg/day), Q3 (22.87-32.28 mg/day) and Q4 (≥ 32.29 mg/day), were 0.92 (95% CI: 0.70-1.20), 0.76 (95% CI: 0.56-0.99,) and 0.68 (95% CI: 0.48-0.98), respectively. The results were not modified by sex, by age and by BMI. Furthermore, the relationship between dietary niacin intake and depression exhibited a U-shaped curve (nonlinear, p < 0.001). And depression risk was lowest when dietary consumption of niacin was around 36 mg/day.
conclusionsIn present study, moderate niacin intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped association.
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