ArticleBMC neurology2023
Retinal functional and structural changes in patients with Parkinson's disease.
Article in BMC neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Eye-Tracking Assessment of Visual, Oculomotor, and Pupillary Biomarkers During Reading in Parkinson's Disease.Life (Basel, Switzerland) · 2026Article
- From clutter to confidence: home environmental triggers and adaptive solutions for freezing of gait in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Improving Parkinson's disease diagnosis by non-invasive detection of retinal biomarkers in MPTP monkeys using ERG and pupillometry.NPJ Parkinson's disease · 2026Article
- The Retina as a Proxy for Brain Neurodegeneration: A Narrative Review on OCT-Based Retinal Imaging in the Early Detection of Alzheimer's and Parkinson's Disease.Journal of imaging · 2026Review
- Early retinal synaptic dysfunction and proteomic remodeling precede neurodegeneration in a Parkinson's disease model.NPJ Parkinson's disease · 2026Article
- The Retina as a Biomarker for Parkinson's Disease: A Systematic Review.Neuro-ophthalmology (Aeolus Press) · 2026Review
- Retinal alterations resemble brain pathology in a rat model of Parkinson's disease induced by intranigral infusion of α-synuclein oligomers.Cell death discovery · 2025Article
- Synthetic electroretinogram signal generation using a conditional generative adversarial network.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Time Series Classification of Autism Spectrum Disorder Using the Light-Adapted Electroretinogram.Bioengineering (Basel, Switzerland) · 2025Article
- Retinal Neurovascular Signatures in Parkinson's Disease.Investigative ophthalmology & visual science · 2025Article
- Pupillographic evaluation accompanying structural and functional assessment of the optic nerve in patients with Parkinson's disease.BMC ophthalmology · 2025Article
- Brief report: effects of methylphenidate on the light adapted electroretinogram.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Spectral Analysis of Light-Adapted Electroretinograms in Neurodevelopmental Disorders: Classification with Machine Learning.Bioengineering (Basel, Switzerland) · 2024Article
- Structural changes in the retina as a potential biomarker in Parkinson's disease: an approach from optical coherence tomography.Frontiers in neuroimaging · 2024Article
- Generating Synthetic Light-Adapted Electroretinogram Waveforms Using Artificial Intelligence to Improve Classification of Retinal Conditions in Under-Represented Populations.Journal of ophthalmology · 2024Article
- Is relying on RNFL specific enough to identify any changes in the CNS?Advances in ophthalmology practice and researchArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVisual dysfunction have been well reported as one of the non-motor symptoms in Parkinson's disease (PD). The aim of this study was to evaluate the functional and structural changes in the retina in patients with PD, and to correlate these changes with disease duration and motor dysfunction.
methodsFor this case-control study, we recruited patients fulfilling the diagnostic criteria for idiopathic PD according to British Brain Bank criteria, aged between 50 and 80 years. Age- and sex-matched healthy controls aged between 50 and 80 years were also recruited. Motor function for PD patients was assessed using Modified Hoehn and Yahr staging scale (H & Y staging) and Unified Parkinson's Disease Rating Scale (UPDRS). Optical Coherence Tomography (OCT) and full field electroretinogram (ff-ERG) were done to all participants.
resultsData from 50 patients and 50 healthy controls were included in the analysis. Patients with idiopathic Parkinson's had significantly reduced peripapillary retinal nerve fiber layer (RNFL) thickness and macular ganglion cell complex (GCC) thickness compared to healthy controls (P-value < 0.05 in all parameters). They also had significantly delayed latency and reduced amplitude in both dark-adapted rods and the light-adapted cone for both a & b waves compared to healthy controls (P-value < 0.001 in all parameters). There were statistically significant negative correlations between disease duration, and left superior, right inferior and right & left average RNFL thickness [(r) coef. = -0.327, -0.301, -0.275, and -0.285 respectively]. UPDRS total score was negatively correlated with the amplitude of light-adapted of both RT and LT a & b wave and with dark-adapted RT b-wave latency [(r) coef. = -0.311, -0.395, -0.362, -0.419, and -0.342].
conclusionThe retinal structure and function were significantly affected in patients with PD in comparison to healthy controls. There was a significant impact of disease duration on retinal thickness, and there was a significant negative correlation between the degree of motor dysfunction in patients with PD and retinal function.
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