Evidence map›Paper›PMID 37723298›Full record

ArticleNature cell biology2023

A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila.

Zsolt G Venkei, Ildar Gainetdinov, Ayca Bagci, Margaret R Starostik, Charlotte P Choi, Jaclyn M Fingerhut, Peiwei Chen, Chiraag Balsara, Troy W Whitfield, George W Bell and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cell biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Zsolt G Venkei *Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ildar Gainetdinov *RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0003-1719-043X
Ayca BagciRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Margaret R StarostikDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-5274-2765
Charlotte P ChoiDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA.
Jaclyn M FingerhutWhitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-2347-0799
Peiwei ChenDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0001-7160-6673
Chiraag BalsaraLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Troy W WhitfieldWhitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-2026-4201
George W BellWhitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Suhua FengDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA.
Steven E JacobsenDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA.ORCID 0000-0001-9483-138X
Alexei A AravinDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0002-6956-8257
John K KimDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA.
Phillip D ZamoreRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA. phillip.zamore@umassmed.edu.ORCID 0000-0002-4505-9618
Yukiko M YamashitaWhitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. yukikomy@wi.mit.edu.ORCID 0000-0001-5541-0216
Howard Hughes Medical Institute · USJohns Hopkins University · USWhitehead Institute for Biomedical Research · USCalifornia Institute of Technology · USUniversity of Massachusetts Chan Medical School · USUniversity of California, Los Angeles · USUniversity of Michigan · US

Funding

Molecular Mechanism of the piRNA BiogenesisR01GM097363 · NIGMS · CORNELL UNIVERSITY · PI ARAVIN, ALEXEI A. · 2011 to 2025
$4.0M
Understanding the Evolution, Biology, and Molecular Mechanism of Argonaute ProteinsR35GM136275 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI PHILLIP D ZAMORE · 2020 to 2026
$3.3M
Sexual dimorphism of piRNA transcription and target silencing mechanisms in C. elegansR01HD109667 · NICHD · JOHNS HOPKINS UNIVERSITY · PI John Kim · 2022 to 2026
$2.4M
Epigenetic gene regulation in ArabidopsisR35GM130272 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JACOBSEN, STEVEN E · 2019 to 2023
$1.6M
NICHD NIH HHS R01 HD109667NIGMS NIH HHS R01 GM097363NIGMS NIH HHS R35 GM130272NIGMS NIH HHS R35 GM136275
6 · The paper itself

Abstract

In animals, PIWI-interacting RNAs (piRNAs) direct PIWI proteins to silence complementary targets such as transposons. In Drosophila and other species with a maternally specified germline, piRNAs deposited in the egg initiate piRNA biogenesis in the progeny. However, Y chromosome loci cannot participate in such a chain of intergenerational inheritance. How then can the biogenesis of Y-linked piRNAs be initiated? Here, using Suppressor of Stellate (Su(Ste)), a Y-linked Drosophila melanogaster piRNA locus as a model, we show that Su(Ste) piRNAs are made in the early male germline via 5'-to-3' phased piRNA biogenesis initiated by maternally deposited 1360/Hoppel transposon piRNAs. Notably, deposition of Su(Ste) piRNAs from XXY mothers obviates the need for phased piRNA biogenesis in sons. Together, our study uncovers a developmentally programmed, intergenerational mechanism that allows fly mothers to protect their sons using a Y-linked piRNA locus.

Indexed as

DrosophilaDrosophila ProteinsAnimalsArgonaute ProteinsDrosophila melanogasterPiwi-Interacting RNARNA, Small InterferingArgonaute ProteinsDrosophila ProteinsPiwi-Interacting RNARNA, Small Interfering

Identifiers

PMID37723298
PMCPMC10567549
OpenAlexW4386827098

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.