ArticleNature genetics2023
Molecular basis for maternal inheritance of human mitochondrial DNA.
Open access · greenAbstract readLetter
In one paragraph
Article in Nature genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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0cells of the map it votes in
59citing papers in PubMed
13.2field-weighted citation impact, top 1% of its field
What it found
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Who cites it
59 citing papers in PubMed, 86 citations in OpenAlex.
- Inheritance and selection of the mitochondrial genome.Nature reviews. Genetics · 2026Review
- The factory enters the fray: how mitochondrial protein trafficking shapes the host response to infection.Journal of virology · 2026Review
- Maternal age as a driver of genome instability: mechanisms linking aneuploidy, mutagenesis and mitochondrial dysfunction.Archives of toxicology · 2026Review
- Sperm mitochondrial DNA copy number: a marker of male fertility and reproductive success.Human reproduction update · 2026Review
- Cell-type-resolved RNA-seq reveals molecular signatures of sexual experience inNAR genomics and bioinformatics · 2026Article
- Shifting the Balance: Mitochondrial Heteroplasmy as a Driver of Cardiac Disease.Circulation research · 2026Review
- Circadian Disruption Is Associated with Elevated Whole-Semen mtDNA Copy Number and ImplicatesInternational journal of molecular sciences · 2026Article
- Current state of the art in the transmission of mitochondrial DNA pathogenic variants: reviewing preventive-therapeutic alternatives.Journal of assisted reproduction and genetics · 2026Review
- Testicular origin of epigenetic inheritance independent of sperm mitochondrial DNA and epididymal exposure.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sex-dependent differences in mitochondrial protein acetylation in metabolic condition, oxidative stress, vascular dysfunction, hypertension, and cardiovascular disease.Clinical science (London, England : 1979) · 2026Review
- Phylogeny and Selection Pressure of GenusAnimals : an open access journal from MDPI · 2026Article
- Modulation of Microbiome-Mitochondria Axis as a Novel Approach for Treatment of Obesity: A Scoping Review.Medical sciences (Basel, Switzerland) · 2026Article
- Evidence for Paternal Mitochondrial DNA Leakage in Diploid Hybrid Fish Lineages.Animals : an open access journal from MDPI · 2026Article
- ALKB-1-dependent tRNA methylation is required for efficient paternal mitochondrial elimination.Nature communications · 2026Article
- Unstable mitochondrial heteroplasmy inPeerJ · 2026Article
- The nuclear and mitochondrial genomes need to tango. How is their dance synchronized during development?NAR molecular medicine · 2026Article
- Gatekeepers of the Germ Line: How Mitochondria Shape Reproductive Evolution in Metazoans.Biology · 2025Review
- Ignoring the planet: A critical blind spot for research on ageing.Journal of internal medicine · 2025Review
- Decoding nuclear-encoded mitochondrial genes in major depressive disorder: A multi-omics perspective.Psychological medicine · 2025Article
- Molecular machineries and pathways of mitochondrial protein transport.Nature reviews. Molecular cell biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 2 countries.
William Lee *Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-0133-9076
Angelica Zamudio-Ochoa *Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Gina Buchel *Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-5266-2477
Petar PodlesniyNeurobiology Unit, Institut d'Investigacions Biomèdiques de Barcelona (IIBB-CSIC-IDIBAPS) and Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.
Nuria Marti GutierrezCenter for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA.
Margalida PuigròsNeurobiology Unit, Institut d'Investigacions Biomèdiques de Barcelona (IIBB-CSIC-IDIBAPS) and Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.ORCID http://orcid.org/0000-0002-7891-5919
Anna CalderonNeurobiology Unit, Institut d'Investigacions Biomèdiques de Barcelona (IIBB-CSIC-IDIBAPS) and Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.
Hsin-Yao TangMolecular & Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1838-018X
Li LiDepartment of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, USA.
Aleksei MikhalchenkoCenter for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA.
Amy KoskiCenter for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA.
Ramon TrullasNeurobiology Unit, Institut d'Investigacions Biomèdiques de Barcelona (IIBB-CSIC-IDIBAPS) and Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.ORCID http://orcid.org/0000-0001-7951-9881
Shoukhrat MitalipovCenter for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA.
Dmitry TemiakovDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA. dmitry.temiakov@jefferson.edu.ORCID http://orcid.org/0000-0001-5497-3068
Thomas Jefferson University · USBiomedical Research Networking Center on Neurodegenerative Diseases · ESOregon Health & Science University · USThe Wistar Institute · US
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1MTumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9MMolecular Mechanisms of Mitochondrial Transcription and ReplicationR35GM131832 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI Dmitry Temiakov · 2019 to 2026
$4.3MAdvancing Cancer Research through Comprehensive Proteomics and Metabolomics AnalysesR50CA221838 · NCI · WISTAR INSTITUTE · PI Hsin-Yao Tang · 2017 to 2026
$2.1MNCI NIH HHS P30 CA010815NCI NIH HHS P30 CA016087NCI NIH HHS R50 CA221838NIGMS NIH HHS R35 GM131832
Abstract
Uniparental inheritance of mitochondrial DNA (mtDNA) is an evolutionary trait found in nearly all eukaryotes. In many species, including humans, the sperm mitochondria are introduced to the oocyte during fertilization
Indexed as
DNA, MitochondrialMaternal InheritanceHumansMaleMitochondriaMitochondrial ProteinsSemenSpermatozoaDNA, MitochondrialMitochondrial Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.