ArticleCommunications biology2023
Positive and biphasic extracellular waveforms correspond to return currents and axonal spikes.
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Article
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- Large-scale electrophysiology at single-spike resolution.Nature reviews. Neuroscience · 2026Review
- Laminar organization of cellular microcircuits modulating human interictal epileptiform discharges.Nature neuroscience · 2026Article
- Extracellular Spike Waveforms: Morphology, Biophysics, and Classification Strategies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Neuropixels reveal laminar microcircuit organization in monkey V1 in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- High performance sorting of motor unit action potentials with EMUsort.bioRxiv : the preprint server for biology · 2026Article
- Ultra-high-density Neuropixels probes improve detection and identification in neuronal recordings.Neuron · 2025Article
- Alpha Modulation of Spiking Activity Across Multiple Brain Regions in Mice Performing a Tactile Selective Detection Task.The European journal of neuroscience · 2025Article
- SLAy-ing oversplitting errors in high-density electrophysiology spike sorting.bioRxiv : the preprint server for biology · 2025Article
- Enriched experience increases reciprocal synaptic connectivity and coding sparsity in higher-order cortex.bioRxiv : the preprint server for biology · 2025Article
- Neuropixels reveal structure-function relationships in monkey V1bioRxiv : the preprint server for biology · 2025Article
- Article
- Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices.Nature neuroscience · 2024Article
- Circuit dynamics of superficial and deep CA1 pyramidal cells and inhibitory cells in freely-moving macaques.bioRxiv : the preprint server for biology · 2024Article
- Ultra-high density electrodes improve detection, yield, and cell type identification in neuronal recordings.bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
Multiple biophysical mechanisms may generate non-negative extracellular waveforms during action potentials, but the origin and prevalence of positive spikes and biphasic spikes in the intact brain are unknown. Using extracellular recordings from densely-connected cortical networks in freely-moving mice, we find that a tenth of the waveforms are non-negative. Positive phases of non-negative spikes occur in synchrony or just before wider same-unit negative spikes. Narrow positive spikes occur in isolation in the white matter. Isolated biphasic spikes are narrower than negative spikes, occurring right after spikes of verified inhibitory units. In CA1, units with dominant non-negative spikes exhibit place fields, phase precession, and phase-locking to ripples. Thus, near-somatic narrow positive extracellular potentials correspond to return currents, and isolated non-negative spikes correspond to axonal potentials. Identifying non-negative extracellular waveforms that correspond to non-somatic compartments during spikes can enhance the understanding of physiological and pathological neural mechanisms in intact animals.
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