Evidence map›Paper›PMID 37723115›Full record

ArticleBMJ open2023

Soluble C-type lectin-like receptor 2 in stroke (CLECSTRO) study: protocol of a multicentre, prospective cohort of a novel platelet activation marker in acute ischaemic stroke and transient ischaemic attack.

Shinichiro Uchiyama, Katsue Suzuki-Inoue, Hideo Wada, Yasushi Okada, Teruyuki Hirano, Takehiko Nagao, Hiroyuki Kinouchi, Ryo Itabashi, Haruhiko Hoshino, Koichi Oki and 4 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05579405 (Soluble C-type Lectin-Like Receptor 2 in Stroke Study), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05579405 unknown statusnot on this map

Soluble C-type Lectin-Like Receptor 2 in Stroke Study

TypeobservationalSponsorUniversity of YamanashiRan2022 to 2024Enrolled600ConditionsAcute Ischemic Stroke, Transient Ischemic Attack
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Super Formula for Soluble C-Type Lectin-Like Receptor 2 × D-Dimer in Patients With Acute Cerebral Infarction.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shinichiro UchiyamaClinical Research Center for Medicine, International University of Health and Welfare, Tokyo, Japan suchiyama@iuhw.ac.jp.ORCID 0000-0002-6280-8190
Katsue Suzuki-InoueDepartment of Clinical and Laboratory Medicine, University of Yamanashi, Chuo, Japan.ORCID 0000-0001-9678-1451
Hideo WadaDepartment of General and Laboratory Medicine, Mie Prefectural General Medical Centre, Yokkaichi, Japan.ORCID 0000-0001-9021-8633
Yasushi OkadaDepartment of Cerebrovascular Medicine and Neurology, National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan.ORCID 0000-0002-3150-6157
Teruyuki HiranoDepartment of Stroke and Cerebrovascular Medicine, Kyorin University, Mitaka, Japan.ORCID 0000-0003-2094-2428
Takehiko NagaoDepartment of Neurology, Nippon Medical School Musashikosugi Hospital, Kawasaki, Japan.ORCID 0000-0001-5289-2467
Hiroyuki KinouchiDepartment of Neurosurgery, University of Yamanashi, Chuo, Japan.ORCID 0000-0003-0841-5502
Ryo ItabashiDivision of Neurology & Gerontology, Iwate Medical University, Shiwa, Japan.ORCID 0000-0001-8098-457X
Haruhiko HoshinoDepartment of Neurology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.ORCID 0000-0001-8151-3796
Koichi OkiDepartment of Neurology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.ORCID 0000-0003-2640-3337
Yutaka HonmaDepartment of Neurology, Showa General Hospital, Kodaira, Japan.ORCID 0000-0002-0609-7769
Nobuo ItoDepartment of Neurology, Mie Prefectural General Medical Centre, Yokkaichi, Japan.ORCID 0000-0001-6549-8880
Hiroshi SugimoriDepartment of Cerebrovascular Medicine and Neurology, National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan.ORCID 0000-0002-1135-1653
Masahide KawamuraDepartment of Research and Development, LSI Medience Corporation, Tokyo, Japan.ORCID 0000-0002-9495-2314

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSoluble C-type lectin-like receptor 2 (sCLEC-2) is a new biomarker for platelet activation, which can be easily measured by usual blood collection. We conducted the CLECSTRO, a prospective, observational cohort study, to evaluate the clinical implications of sCLEC-2 in patients with acute ischaemic stroke (AIS) and transient ischaemic attack (TIA). METHODS AND ANALYSIS: The participants are patients with AIS/TIA and control patients required for differentiation from AIS/TIA. The target population is 600, including the patients and controls, who would be recruited from eight stroke centres across Japan. The inclusion criteria are AIS within 24 hours of onset and a modified Rankin Scale (mRS) score of 0-2, TIA within 7 days of onset, and contemporary patients required for differentiation from AIS/TIA. Plasma sCLEC-2 will be measured by high-sensitive chemiluminescent enzyme immunoassay using residual blood samples from routine laboratory examinations at the first visit in all patients and 7 days later or at discharge in patients with AIS/TIA. The outcomes include plasma levels of sCLEC-2 in patients with AIS/TIA and controls, sCLEC-2/D-dimer ratio in non-cardioembolic and cardioembolic AIS/TIA, correlation of sCLEC-2 with recurrence or worsening of stroke, severity of stroke, infarct size, ABCD ETHICS AND DISSEMINATION: This study was approved by the Ethical Committee of the University of Yamanashi as the central ethical committee in agreement with the ethical committees of all collaborative stroke centres. Informed consent will be obtained by an opt-out form from the patients at each stroke centre according to the Ethical Guidelines for Medical and Biological Research Involving Human Subjects by the Japanese Ministry of Health, Labour and Welfare. TRIAL REGISTRATION NUMBERS: NCT05579405, UMIN000048954.

Indexed as

Brain IschemiaIschemic Attack, TransientIschemic StrokeStrokeHumansLectins, C-TypeMulticenter Studies as TopicObservational Studies as TopicProspective StudiesCLEC1B protein, humanLectins, C-TypeStrokeStroke medicine

Identifiers

PMID37723115
PMCPMC10510909

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.