Evidence map›Paper›PMID 37722671›Full record

ArticleACS infectious diseases2023

Identification of and Structural Insights into Hit Compounds Targeting

Michael K Fenwick, Alexandra R Reers, Yi Liu, Rachael Zigweid, Banumathi Sankaran, Janis Shin, Matthew A Hulverson, Bradley Hammerson, Elena Fernández Álvaro, Peter J Myler and 4 more

Open access · hybridAbstract read
In one paragraph

Article in ACS infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Exploring Subsite Selectivity withinJournal of medicinal chemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Michael K FenwickSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98109, United States.
Alexandra R ReersSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98109, United States.
Yi LiuDepartment of Biochemistry, University of Washington, Seattle, Washington 98195, United States.ORCID 0000-0003-1513-8638
Rachael ZigweidSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98109, United States.
Banumathi SankaranBerkeley Center for Structural Biology, Advanced Light Source, Berkeley National Laboratory, Berkeley, California 94720, United States.
Janis ShinSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98109, United States.ORCID 0000-0002-1657-2455
Matthew A HulversonCenter for Emerging and Re-emerging Infectious Diseases, Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington 98109, United States.ORCID 0000-0002-3413-4969
Bradley HammersonSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98109, United States.
Elena Fernández ÁlvaroGSK Global Health, C/ Severo Ochoa, n° 2 Tres Cantos, 28760 Madrid, Spain.
Peter J MylerSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98109, United States.
Alexis KaushanskyCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington 98109, United States.ORCID 0000-0001-5721-258X
Wesley C Van VoorhisSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98109, United States.
Erkang FanDepartment of Biochemistry, University of Washington, Seattle, Washington 98195, United States.
Bart L StakerSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98109, United States.ORCID 0000-0001-9570-5086
Center for Infectious Disease Research · USUniversity of Washington · USInfectious Disease Research Institute · USLawrence Berkeley National Laboratory · US

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
Centers for Research on Structural Biology of Infectious Diseases: Universal Influenza Vaccine Research75N93022C00036 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI STAKER, BART · 2022 to 2025
$21.7M
Structural Analysis and Inhibitor Optimization of Cryptosporidium n-myristoyltransferase for Drug DiscoveryR01AI155536 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI STAKER, BART LEE · 2021 to 2025
$4.2M
Structural Analysis and inhibitor optimization of Cryptosporidium n-myristoyltransferase for drug discoveryR21AI137815 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI STAKER, BART LEE · 2018 to 2019
$491k
NIAID NIH HHS 75N93022C00036NIAID NIH HHS HHSN272201700059CNIAID NIH HHS R01 AI155536NIAID NIH HHS R21 AI137815NIGMS NIH HHS P30 GM124169
6 · The paper itself

Abstract

Each year, approximately 50,000 children under 5 die as a result of diarrhea caused by

Indexed as

CryptosporidiosisCryptosporidiumPlasmodiumAcyltransferasesChildDrug DevelopmentHumansAcyltransferasesglycylpeptide N-tetradecanoyltransferasechildhood infectious diseaseCryptosporidiumdrug discoveryN-myristoyltransferase

Identifiers

PMID37722671
PMCPMC10580320
OpenAlexW4386821017

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.