Evidence map›Paper›PMID 37722619›Full record

ArticleFungal genetics and biology : FG & B2023

The histone demethylase KdmB is part of a trimeric protein complex and mediates virulence and mycotoxin production in Penicillium expansum.

Dianiris Luciano-Rosario, Omer Barda, Joanna Tannous, Dean Frawley, Özgür Bayram, Dov Prusky, Edward Sionov, Nancy P Keller

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fungal genetics and biology : FG & B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Dianiris Luciano-RosarioDepartment of Plant Pathology, University of Wisconsin, Madison, WI, USA.
Omer BardaInstitute of Postharvest and Food Sciences, Volcani Center, Agricultural Research Organization, Rishon LeZion, Israel.
Joanna TannousBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, USA.
Dean FrawleyFaculty of Science and Engineering, National University of Ireland Maynooth, Kildare, Ireland.
Özgür BayramFaculty of Science and Engineering, National University of Ireland Maynooth, Kildare, Ireland.
Dov PruskyInstitute of Postharvest and Food Sciences, Volcani Center, Agricultural Research Organization, Rishon LeZion, Israel.
Edward SionovInstitute of Postharvest and Food Sciences, Volcani Center, Agricultural Research Organization, Rishon LeZion, Israel.
Nancy P KellerDepartment of Plant Pathology, University of Wisconsin, Madison, WI, USA; Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI, USA. Electronic address: npkeller@wisc.edu.
Agricultural Research Organization · ILNational University of Ireland, Maynooth · IEUniversity of Wisconsin–Madison · USOak Ridge National Laboratory · US

Funding

Microbial Pathogenesis &Host Responses Training ProgramT32AI055397 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2003 to 2024
$5.5M
NIAID NIH HHS T32 AI055397
6 · The paper itself

Abstract

Epigenetic modification of chromosome structure has increasingly been associated with alterations in secondary metabolism and sporulation defects in filamentous fungal pathogens. Recently, the epigenetic reader protein SntB was shown to govern virulence, spore production and mycotoxin synthesis in the fruit pathogen Penicillium expansum. Through immunoprecipitation-coupled mass spectrometry, we found that SntB is a member of a protein complex with KdmB, a histone demethylase and the essential protein RpdA, a histone deacetylase. Deletion of kdmB phenocopied some but not all characteristics of the ΔsntB mutant. KdmB deletion strains exhibited reduced lesion development on Golden Delicious apples and this was accompanied by decreased production of patulin and citrinin in host tissue. In addition, ΔkdmB mutants were sensitive to several cell wall stressors which possibly contributed to the decreased virulence observed on apples. Slight differences in spore production and germination rates of ΔkdmB mutants in vitro did not impact overall diameter growth in culture.

Indexed as

MalusPatulinPenicilliumFruitVirulencePatulinEpigeneticsFungal biologyMycotoxinPost-harvest diseaseSecondary metabolismVirulence

Identifiers

PMID37722619
PMCPMC10755807
OpenAlexW4386799871

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.