Evidence map›Paper›PMID 37722602›Full record

ArticleNature2023

Cholinergic neurons trigger epithelial Ca

Afroditi Petsakou, Yifang Liu, Ying Liu, Aram Comjean, Yanhui Hu, Norbert Perrimon

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Monosodium glutamate-mediated CaPhysiological reports · 2026
    Article
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  8. Article
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  10. Article
  11. Review
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  19. Review
  20. Cell-death induced immune response and coagulopathy promote cachexia inbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Afroditi PetsakouDepartment of Genetics, Harvard Medical School, Boston, MA, USA. Afroditi_Petsakou@hms.harvard.edu.ORCID 0000-0002-9612-5929
Yifang LiuDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5382-640X
Ying LiuDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6419-1980
Aram ComjeanDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-4125-0703
Yanhui HuDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1494-1402
Norbert PerrimonDepartment of Genetics, Harvard Medical School, Boston, MA, USA. perrimon@genetics.med.harvard.edu.ORCID 0000-0001-7542-472X
Harvard University · USHoward Hughes Medical Institute · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Functional genomics resources for the Drosophila - TR&D3P41GM132087 · NIGMS · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2019 to 2023
$6.8M
NIDDK NIH HHS P30 DK043351NIGMS NIH HHS P41 GM132087
6 · The paper itself

Abstract

A fundamental and unresolved question in regenerative biology is how tissues return to homeostasis after injury. Answering this question is essential for understanding the aetiology of chronic disorders such as inflammatory bowel diseases and cancer

Indexed as

CalciumCalcium SignalingCholinergic NeuronsDrosophila melanogasterEnterocytesIntestinesAcetylcholineAcetylcholinesteraseAnimalsConnexinsDisease Models, AnimalDrosophila ProteinsHomeostasisHumansInflammationInflammatory Bowel DiseasesAcetylcholineAcetylcholinesteraseCalciumConnexinsDrosophila Proteinsegr protein, Drosophilainx2 protein, Drosophilainx7 protein, DrosophilaMembrane ProteinsReceptors, NicotinicYAP-Signaling ProteinsYki protein, Drosophila

Identifiers

PMID37722602
PMCPMC10699467
OpenAlexW4386826855

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.