Trial reportPsychiatry research2023
Neurofeedback for obsessive compulsive disorder: A randomized, double-blind trial.
Trial report in Psychiatry research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02206945 (Neurofeedback of Activity in the Orbitofrontal Cortex for OCD), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neurofeedback of Activity in the Orbitofrontal Cortex for OCD
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- The Efficacy of Virtual Reality-Based EEG Neurofeedback in Health-Related Symptoms Relief: A Systematic Review.Applied psychophysiology and biofeedback · 2025Pooled it
- Neurofeedback as an Adjunct to Pharmacotherapy in OCD: A Randomized Controlled Trial on Symptom Reduction.Applied psychophysiology and biofeedback · 2026Trial
- Neurofeedback interventions for obsessive-compulsive and related disorders: Current evidence and future directions.Journal of psychiatric research · 2026Review
- Brain-computer interface: an update for the clinicians.Frontiers in human neuroscience · 2026Review
- Classifying Obsessive-Compulsive Disorder from Resting-State EEG Using Convolutional Neural Networks: A Pilot Study.Computational psychiatry (Cambridge, Mass.) · 2026Article
- Classifying Obsessive-Compulsive Disorder from Resting-State EEG using Convolutional Neural Networks: A Pilot Study.medRxiv : the preprint server for health sciences · 2025Article
- Neurofeedback: new territories and neurocognitive mechanisms of endogenous neuromodulation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Predicting OCD severity from religiosity and personality: A machine learning and neural network approach.Journal of mood and anxiety disorders · 2024Article
- Article
- Identifying brain targets for real-time fMRI neurofeedback in chronic pain: insights from functional neurosurgery.Psychoradiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
We aim to develop fMRI neurofeedback as a treatment for obsessive compulsive disorder (OCD). In prior work, we found that providing neurofeedback of activity in the anterior prefrontal cortex (aPFC) improved control over contamination anxiety in a subclinical population. Here, we present the results of a randomized, double-blind clinical trial (NCT02206945) testing this intervention in patients with OCD. We recruited patients with primary symptoms in the fear-of-harm/checking or contamination/washing domains. During neurofeedback, they viewed symptom provocative images and attempted to up- and down-regulate the aPFC during different blocks of time. The active group received two sessions of neurofeedback and the control group received yoked sham feedback. The primary outcome measure was the Yale-Brown Obsessive-Compulsive Symptom scale. The secondary outcome was control over aPFC. Thirty-six participants completed feedback training (18 active, 18 control). The active group had a slightly but significantly greater reduction of obsessive-compulsive symptoms after neurofeedback compared to the control group (p<.05) but no significant differences in control over the aPFC. These data demonstrate that neurofeedback targeting the aPFC can reduce symptoms in OCD. Future investigations should seek to optimize the training protocol to yield larger effects and to clarify the mechanism of action.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.