ArticleBiomedica : revista del Instituto Nacional de Salud2023
Expression of ERG11, ERG3, MDR1 and CDR1 genes in Candida tropicalis
Article in Biomedica : revista del Instituto Nacional de Salud, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 7 citations in OpenAlex.
- Research progress on the drug resistance mechanisms ofFrontiers in microbiology · 2025Review
- Geraniol Potentiates the Effect of Fluconazole against Planktonic and Sessile Cells of Azole-ResistantPharmaceutics · 2024Article
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4 authors at 2 institutions in 1 country.
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Abstract
introductionDrug resistance to azoles is a growing problem in the Candida genus.
objectiveTo analyze molecularly the genes responsible for fluconazole resistance in Candida tropicalis strains. MATERIALS AND
methodsNineteen strains, with and without exposure to fluconazole, were selected for this study. The expression of MDR1, CDR1, ERG11, and ERG3 genes was analyzed in sensitive, dose-dependent sensitive, and resistant strains exposed to different concentrations of the antifungal drug.
resultsMDR1, ERG11 and ERG3 genes were significantly overexpressed in the different sensitivity groups. CDR1 gene expression was not statistically significant among the studied groups. Seven of the eight fluconazole-resistant strains showed overexpression of one or more of the analyzed genes. In some dose-dependent sensitive strains, we found overexpression of CDR1, ERG11, and ERG3.
conclusionThe frequency of overexpression of ERG11 and ERG3 genes indicates that they are related to resistance. However, the finding of dose-dependent resistant/sensitive strains without overexpression of these genes suggests that they are not exclusive to this phenomenon. More basic research is needed to study other potentially involved genes in the resistance mechanism to fluconazole.
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