Evidence map›Paper›PMID 37721804›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2024

Enzymatic Resolution and Decarboxylative Functionalization of α-Sulfinyl Esters.

Suraksha Gahalawat, Yesu Addepalli, Stephen P Fink, Lakshmi Kasturi, Sanford D Markowitz, Joseph M Ready

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Suraksha GahalawatDepartment of Biochemistry, University of Texas Southwestern Medical Center, 75390-9038, Dallas, Texas, USA.
Yesu AddepalliDepartment of Biochemistry, University of Texas Southwestern Medical Center, 75390-9038, Dallas, Texas, USA.
Stephen P FinkCase Comprehensive Cancer Center, Case Western Reserve University, 44106, Cleveland, Ohio, USA.
Lakshmi KasturiDepartment of Medicine, Case Western Reserve University, 44106, Cleveland, Ohio, USA.
Sanford D MarkowitzCase Comprehensive Cancer Center and Department of Medicine, Case Western Reserve University, Seidman Cancer Center, University Hospitals of Cleveland, 44106, Cleveland, Ohio, USA.
Joseph M ReadyDepartment of Biochemistry, University of Texas Southwestern Medical Center, 75390-9038, Dallas, Texas, USA.ORCID https://orcid.org/0000-0003-1305-9581
The University of Texas Southwestern Medical Center · USCase Western Reserve University · USUniversity Hospitals of Cleveland · US

Funding

Chemical, Structural and Cell-Signaling Interrogation of 15-Prostanglandin Dehydrogenase in Tissue Repair and RegenerationRM1GM142002 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI MARKOWITZ, SANFORD D., PIEPER, ANDREW A · 2021 to 2025
$6.9M
NIGMS NIH HHS RM1 GM142002NIGMS NIH HHS RM1GM142002
6 · The paper itself

Abstract

α-Sulfinyl esters can be readily prepared through thiol substitution of α-bromo esters followed by oxidation to the sulfoxide. Enzymatic resolution with lipoprotein lipase provides both the unreacted esters and corresponding α-sulfinyl carboxylic acids in high yields and enantiomeric ratios. Subsequent decarboxylative halogenation, dihalogenation, trihalogenation and cross-coupling gives rise to functionalized sulfoxides. The method has been applied to the asymmetric synthesis of a potent inhibitor of 15-prostaglandin dehydrogenase.

Indexed as

Carboxylic AcidsEstersHalogenationStereoisomerismSulfoxidesCarboxylic AcidsEstersSulfoxidesdecarboxylationhalogenationlipaseresolutionsulfoxides

Identifiers

PMID37721804
PMCPMC10872298
OpenAlexW4386826798

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.