Evidence map›Paper›PMID 37721487›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2023

Associations between Longer Leukocyte Telomere Length and Increased Lung Cancer Risk among Never Smokers in Urban China.

Jason Y Y Wong, Xiao-Ou Shu, Wei Hu, Batel Blechter, Jianxin Shi, Kevin Wang, Richard Cawthon, Qiuyin Cai, Gong Yang, Mohammad L Rahman and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Jason Y Y WongEpidemiology and Community Health Branch, National Heart Lung and Blood Institute, Bethesda, Maryland.ORCID 0000-0003-2820-2133
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.ORCID 0000-0002-0711-8314
Wei HuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.ORCID 0000-0002-4138-7905
Batel BlechterDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.ORCID 0000-0001-7610-2554
Jianxin ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.ORCID 0000-0001-8606-4707
Kevin WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.ORCID 0009-0005-5143-6909
Richard CawthonDepartment of Human Genetics, University of Utah, Salt Lake City, Utah.ORCID 0000-0001-6073-9112
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.ORCID 0000-0002-9384-5648
Gong YangDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.ORCID 0000-0002-7006-5825
Mohammad L RahmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.ORCID 0000-0001-8322-0495
Bu-Tian JiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.ORCID 0000-0002-8000-4997
Yutang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.ORCID 0000-0003-3904-1777
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.ORCID 0000-0003-1226-070X
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.ORCID 0000-0001-6924-0895
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.ORCID 0000-0002-0888-8839
National Cancer Institute · USVanderbilt University · USNational Heart Lung and Blood Institute · USRenji Hospital · CNUniversity of Utah · US

Funding

Studies of Occupational CancerZIACP010120 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI LAN, QING · 2009 to 2025
$34.4M
Cohort Study of Cancer inhibitory Factors in MenR01CA082729 · NCI · VANDERBILT UNIVERSITY · PI SHU, XIAO-OU · 2001 to 2011
$6.3M
Shanghai Men's Health StudyUM1CA173640 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHU, XIAO-OU · 2013 to 2017
$4.9M
CANCER RISK REDUCTION AND DIET--A COHORT STUDY OF WOMENR01CA070867 · NCI · VANDERBILT UNIVERSITY · PI ZHENG, WEI · 1996 to 2007
$4.6M
Biological mechanisms underlying the relationships between environmental exposures and risk of respiratory and cardiovascular diseasesZIAHL006285 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI WONG, JASON · 2023 to 2025
$3.8M
Intramural NIH HHS Z99 HL999999Intramural NIH HHS ZIA CP010120Intramural NIH HHS ZIA HL006285NCI NIH HHS R01 CA070867NCI NIH HHS R01 CA082729NCI NIH HHS UM1 CA173640
6 · The paper itself

Abstract

backgroundThe complex relationship between measured leukocyte telomere length (LTL), genetically predicted LTL (gTL), and carcinogenesis is exemplified by lung cancer. We previously reported associations between longer pre-diagnostic LTL, gTL, and increased lung cancer risk among European and East Asian populations. However, we had limited statistical power to examine the associations among never smokers by gender and histology.

methodsTo investigate further, we conducted nested case-control analyses on an expanded sample of never smokers from the prospective Shanghai Women's Health Studies (798 cases and 792 controls) and Shanghai Men's Health Studies (161 cases and 162 controls). We broke the case-control matching and used multivariable unconditional logistic regression models to estimate the ORs and 95% confidence intervals (CI) of incident lung cancer and adenocarcinoma (LUAD), in relation to LTL measured using quantitative PCR and gTL determined using a polygenic score. In addition, we conducted Mendelian randomization (MR) using MR-PRESSO.

resultsWe found striking dose-response relationships between longer LTL and gTL, and increased lung cancer risk among never-smoking women (P trendLTL = 4×10-6; P trendgTL = 3×10-4). Similarly, among never-smoking men, longer measured LTL was associated with over triple the risk compared with those with the shortest (OR, 3.48; 95% CI, 1.85-6.57). The overall results were similar for LUAD among women and men. MR analyses supported causal associations with LUAD among women (OR1 SD gTL, 1.19; 95% CI, 1.03-1.37; P = 0.03).

conclusionsLonger pre-diagnostic LTL is associated with increased lung cancer risk among never smokers. IMPACT: Our findings firmly support the role of longer telomeres in lung carcinogenesis.

Indexed as

Lung NeoplasmsCarcinogenesisChinaFemaleHumansLeukocytesLungMaleProspective StudiesSmokersTelomereTelomere Homeostasis

Identifiers

PMID37721487
PMCPMC10843003
OpenAlexW4386817506

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.