ArticleHuman brain mapping2023
Sub-voxel quantitative susceptibility mapping for assessing whole-brain magnetic susceptibility from ages 4 to 80.
Article in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Susceptibility Source Separation Unveils Paramagnetic and Diamagnetic Trajectories in Healthy Brains From 5 to 90 Years.NMR in biomedicine · 2026Article
- Sub-voxel QSM reveals the mechanism linking substantia nigra iron and temporal diamagnetism to PD gait.NPJ Parkinson's disease · 2026Article
- Assessing Age-Associated Influences on Paramagnetic and Diamagnetic Susceptibility Maps in Postmortem Human Brains.NMR in biomedicine · 2026Article
- Evaluation of Brain Microstructural Alterations in Preschool Autism Spectrum Disorder: A Voxel-Wise Multimodal MRI Study.Journal of magnetic resonance imaging : JMRI · 2026Article
- Repeatability of Susceptibility Source Separation Methods in Human Brain: A Single-Site Study at 3 T.NMR in biomedicine · 2026Article
- Importance of RMagnetic resonance in medicine · 2026Article
- Longitudinal insights from iron accumulation in motor system of prodromal and clinical Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Human brain R2* transitions across birth from the womb to early infancy.Communications biology · 2025Article
- Brain iron deficiency in children with attention deficit hyperactivity disorder using iterAtive magnetic suscePtibility sources sepARaTion (APART-QSM).Quantitative imaging in medicine and surgery · 2025Article
- Paramagnetic susceptibility measured by magnetic resonance imaging as an in vivo biomarker for iron pathology in epilepsy.Science advances · 2025Article
- So You Want to Image Myelin Using MRI: Magnetic Susceptibility Source Separation for Myelin Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024Review
- Automated segmentation of midbrain nuclei using deep learning and multisequence MRI: A longitudinal study on iron accumulation with age.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Iron load in the normal aging brain measured with QSM andFrontiers in neuroimaging · 2024Article
- Sub-voxel quantitative susceptibility mapping for assessing whole-brain magnetic susceptibility from ages 4 to 80.Human brain mapping · 2023Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolution of magnetic susceptibility of the brain is mainly determined by myelin in white matter (WM) and iron deposition in deep gray matter (DGM). However, existing imaging techniques have limited abilities to simultaneously quantify the myelination and iron deposition within a voxel throughout brain development and aging. For instance, the temporal trajectories of iron in the brain WM and myelination in DGM have not been investigated during the aging process. This study aimed to map the age-related iron and myelin changes in the whole brain, encompassing myelin in DGM and iron deposition in WM, using a novel sub-voxel quantitative susceptibility mapping (QSM) method. To achieve this, a cohort of 494 healthy adults (18-80 years old) was studied. The sub-voxel QSM method was employed to obtain the paramagnetic and diamagnetic susceptibility based on the approximated
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