ReviewEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2023
Cerebral embolic protection during transcatheter heart interventions.
Review in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of Cerebral Embolic Protection Device in Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025Pooled it
- Full Body Embolic Protection During Transcatheter Aortic Valve Replacement in High Risk Patients.JACC. Case reports · 2026Article
- A web-based dynamic nomogram for individualized risk prediction of magnetic resonance imaging-defined cerebral small-vessel disease: Model development and internal validation.The Journal of international medical research · 2026Article
- Cerebral embolic protection (CEP) during transcatheter aortic valve replacement (TAVR) is associated with a lower rate of stroke at a high-volume center.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- The Thromboembolic Continuum in Transcatheter Mitral Valve Repair: A Comprehensive Review.Journal of clinical medicine · 2026Review
- Transcatheter Aortic Valve Implantation in Low-Risk and Younger Patients with Porcelain Aorta: A State-of-the-Art Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Review
- The association of cerebral embolic protection during transcatheter aortic valve replacement with periprocedural neurological outcomes.Frontiers in cardiovascular medicine · 2026Article
- Effectiveness of cerebral embolic protection during transcatheter aortic valve replacement: A systematic review and meta-analysis of randomized trials.International journal of cardiology. Heart & vasculature · 2025Article
- Artificial Intelligence in the Diagnostic Use of Transcranial Doppler and Sonography: A Scoping Review of Current Applications and Future Directions.Bioengineering (Basel, Switzerland) · 2025Review
- Embolic Protection Devices in Transcatheter Aortic Valve Implantation: A Narrative Review of Current Evidence.Journal of clinical medicine · 2025Review
- Management of complications after valvular interventions.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Review
- Neuroprotection Devices in Cardiac Catheterization Laboratories: Does It Sufficiently Protect Our Patients?Medicina (Kaunas, Lithuania) · 2025Review
- Sex Differences in Stroke Following Transcatheter Aortic Valve Replacement and the Role of Embolic Protection Devices in Women.Interventional cardiology (London, England) · 2025Review
- Optimal antithrombotic therapy after transcatheter aortic valve replacement: a comprehensive review.Frontiers in cardiovascular medicine · 2025Review
- Early Outcomes With Cerebral Embolic Protection During Transcatheter Aortic Valve Replacement in Patients With Atrial Fibrillation.Structural heart : the journal of the Heart Team · 2025Article
- Cerebral Embolic Protection: Is There a Benefit for Left Atrial and Mitral Valve Procedures?Current cardiology reports · 2024Review
- Cerebral Embolic Protection Devices: Are There Any Indications in Transcatheter Aortic Valve Replacement?Journal of clinical medicine · 2024Review
- Outcomes and Predictors of Stroke After Transcatheter Aortic Valve Replacement in the Cerebral Protection Device Era.Journal of the American Heart Association · 2024Article
- A Comprehensive Review of Percutaneous and Surgical Left Atrial Appendage Occlusion.Journal of cardiovascular development and disease · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Stroke remains a devastating complication of transcatheter aortic valve replacement (TAVR), with the incidence of clinically apparent stroke seemingly fixed at around 3% despite TAVR's significant evolution during the past decade. Embolic showers of debris (calcium, atheroma, valve material, foreign material) are captured in the majority of patients who have TAVR using a filter-based cerebral embolic protection device (CEPD). Additionally, in systematic brain imaging studies, the majority of patients receiving TAVR exhibit new cerebral lesions. Mechanistic studies have shown reductions in the volume of new cerebral lesions using CEPDs, yet the first randomised trial powered for periprocedural stroke within 72 hours of a transfemoral TAVR failed to meet its primary endpoint of showing superiority of the SENTINEL CEPD. The present review summarises the clinicopathological rationale for the development of CEPDs, the evidence behind these devices to date and the emerging recognition of cerebral embolisation in many non-TAVR transcatheter procedures. Given the uniqueness of each of the various CEPDs under development, specific trials tailored to their designs will need to be undertaken to broaden the CEPD field, in addition to evaluating the role of CEPD in non-TAVR transcatheter heart interventions. Importantly, the cost-effectiveness of these devices will require assessment to broaden the adoption of CEPDs globally.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.