Evidence map›Paper›PMID 37720689›Full record

ArticleOncoimmunology2023

Homogeneity in immune features between colorectal liver metastases better identifies patients with good prognosis compared to pathological response to preoperative chemotherapy.

David Henault, David Stephen, Pierre-Antoine St-Hilaire, Nouredin Messaoudi, Franck Vandenbroucke-Menu, Eve Simoneau, Zhixia Rong, Marylène Plasse, Richard Létourneau, André Roy and 6 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

David HenaultHepato-Pancreato-Biliary Surgery Service, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
David StephenDepartment of Pathology, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
Pierre-Antoine St-HilaireCancer Axis, Centre de recherche du Centre Hospitalier de l'Université de Montréal/Institut du cancer de Montréal, Montréal, Québec, Canada.
Nouredin MessaoudiCancer Axis, Centre de recherche du Centre Hospitalier de l'Université de Montréal/Institut du cancer de Montréal, Montréal, Québec, Canada.
Franck Vandenbroucke-MenuHepato-Pancreato-Biliary Surgery Service, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
Eve SimoneauHepato-Pancreato-Biliary Surgery Service, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
Zhixia RongHepato-Pancreato-Biliary Surgery Service, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
Marylène PlasseHepato-Pancreato-Biliary Surgery Service, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
Richard LétourneauHepato-Pancreato-Biliary Surgery Service, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
André RoyHepato-Pancreato-Biliary Surgery Service, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
Michel DagenaisHepato-Pancreato-Biliary Surgery Service, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
Réal LapointeHepato-Pancreato-Biliary Surgery Service, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
Bich NguyenDepartment of Pathology, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
Anne-Marie Mes-MassonCancer Axis, Centre de recherche du Centre Hospitalier de l'Université de Montréal/Institut du cancer de Montréal, Montréal, Québec, Canada.
G SoucyDepartment of Pathology, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
Simon TurcotteHepato-Pancreato-Biliary Surgery Service, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada.ORCID 0000-0002-9003-812X
Centre Hospitalier de l’Université de Montréal · CAVrije Universiteit Brussel · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In colorectal cancer liver metastases (CRLM), the density of tumor-infiltrating lymphocytes, the expression of class I major histocompatibility complex (MHC-I), and the pathological response to preoperative chemotherapy have been associated with oncological outcomes after complete resection. However, the prognostic significance of the heterogeneity of these features in patients with multiple CRLMs remains under investigation. We used a tissue microarray of 220 mismatch repair-gene proficient CRLMs resected in 97 patients followed prospectively to quantify CD3

Indexed as

Colorectal NeoplasmsLiver NeoplasmsHumansLymphocytes, Tumor-InfiltratingColorectal liver metastasisimmune scoreprognostic biomarkertumor heterogeneitytumor infiltrating lymphocytes

Identifiers

PMID37720689
PMCPMC10503458
OpenAlexW4386742019

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.