Evidence map›Paper›PMID 37720514›Full record

SynthesisFrontiers in medicine2023

Monocyte chemoattractant protein-1 as a potential marker for patients with sepsis: a systematic review and meta-analysis.

Zhuo Chen, Chenwei Li, Jian Yu

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhuo ChenDepartment of Intensive Care Unit, The Second Hospital of Dalian Medical University, Dalian, China.
Chenwei LiDepartment of Pulmonary and Critical Care Medicine, The Second Hospital of Dalian Medical University, Dalian, China.
Jian YuDepartment of Intensive Care Unit, The Second Hospital of Dalian Medical University, Dalian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the diagnostic value of monocyte chemoattractant protein-1 (MCP-1) as a biomarker for adult patients with sepsis. Methods: Related studies on the diagnostic value of MCP-1 in adult patients with sepsis were searched in PubMed, Cochrane Library, Embase, CNKI, CBM, Web of Science, Scopus, and Wanfang Data databases (published to February 20, 2023) was performed if studies assessed the diagnostic accuracy of MCP-1 in adult patients with sepsis and provided appropriate information sufficient to construct a 2 × 2 linked table, studies were included. Results: Data from 8 studies with a total of 805 patients were included. The combined sensitivity was 0.84 (95% CI 0.70-0.92), the specificity was 0.82 (95% CI 0.67-0.91), the combined positive likelihood ratio was 3.711 (2.119-6.500), the negative likelihood ratio was 0.287 (0.198-0.415), and the area under the working characteristic curve for combined subjects was 0.88. The diagnostic odds ratio (DOR) was 16.508 (7.632-35.706). Meta-regression analysis showed that the results were not significant. Deeks' funnel plot showed that there was no publication bias. Conclusion: According to our meta-analysis, MCP-1 is a valuable biomarker and may provide evidence for the diagnosis of sepsis in adults.

Indexed as

biomarkerdiagnosisMCP-1meta-analysissepsis

Identifiers

PMID37720514
PMCPMC10502711

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.