Evidence map›Paper›PMID 37720513›Full record

ReviewFrontiers in medicine2023

Neuroimaging based biotypes for precision diagnosis and prognosis in cancer-related cognitive impairment.

Shelli R Kesler, Ashley M Henneghan, Sarah Prinsloo, Oxana Palesh, Max Wintermark

Abstract readReview
In one paragraph

Review in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shelli R KeslerDivision of Adult Health, School of Nursing, The University of Texas at Austin, Austin, TX, United States.
Ashley M HenneghanDivision of Adult Health, School of Nursing, The University of Texas at Austin, Austin, TX, United States.
Sarah PrinslooDepartment of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Oxana PaleshDepartment of Psychiatry, Virginia Commonwealth University, Richmond, VA, United States.
Max WintermarkDepartment of Neuroradiology, The University of Texas MD Anderson Cancer, Houston, TX, United States.

Funding

Multicenter Randomized Controlled Trial of Brief Behavioral Therapy for Cancer Related InsomniaR01CA239714 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI PALESH, OXANA G · 2020 to 2025
$4.5M
Very-long Term Neurocognitive Outcomes in Breast Cancer Survivors (ProbC2)R01CA172145 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI KESLER, SHELLI R, PALESH, OXANA G · 2012 to 2024
$3.3M
Predicting Long-Term Chemotherapy-Related Cognitive ImpairmentR01CA226080 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI KESLER, SHELLI R, PALESH, OXANA G · 2019 to 2024
$3.1M
Brain Connectivity and Self-Reported Cancer Related Cognitive ImpairmentK01NR018970 · NINR · UNIVERSITY OF TEXAS AT AUSTIN · PI HENNEGHAN, ASHLEY M. · 2020 to 2022
$312k
NCI NIH HHS R01 CA172145NCI NIH HHS R01 CA226080NCI NIH HHS R01 CA239714NINR NIH HHS K01 NR018970
6 · The paper itself

Abstract

Cancer related cognitive impairment (CRCI) is commonly associated with cancer and its treatments, yet the present binary diagnostic approach fails to capture the full spectrum of this syndrome. Cognitive function is highly complex and exists on a continuum that is poorly characterized by dichotomous categories. Advanced statistical methodologies applied to symptom assessments have demonstrated that there are multiple subclasses of CRCI. However, studies suggest that relying on symptom assessments alone may fail to account for significant differences in the neural mechanisms that underlie a specific cognitive phenotype. Treatment plans that address the specific physiologic mechanisms involved in an individual patient's condition is the heart of precision medicine. In this narrative review, we discuss how biotyping, a precision medicine framework being utilized in other mental disorders, could be applied to CRCI. Specifically, we discuss how neuroimaging can be used to determine biotypes of CRCI, which allow for increased precision in prediction and diagnosis of CRCI

Indexed as

biotypescancercognitionneuroimagingprecision medicine

Identifiers

PMID37720513
PMCPMC10499624

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.